Research @ IIDE

Singapore Infectious Diseases Clinical Research Network (SCRN)

Introduction

Singapore Infectious Diseases Clinical Research Network (SCRN) was established in 2013 with funding from Singapore Infectious Diseases Initiative (SIDI) to promote and coordinate multicentre clinical infectious disease research in Singapore. The administrative team is located in Communicable Diseases Centre, Tan Tock Seng Hospital, as part of the Institute of Infectious Diseases and Epidemiology (IIDE).

It is governed by an executive committee comprising principal investigators with funded projects within SCRN, and supported by a project manager, research fellow, network coordinator and a team of research assistants with expertise in patient recruitment. Our study sites include all public and private hospitals in Singapore.

The founding principal investigator for SCRN was Professor LEO Yee-Sin from 2013 to 2014. She was succeeded by Associate Professor David LYE in 2014.

Missions

Our missions are:

  1. To establish long-term research collaboration between clinical infectious disease and microbiology departments in Singapore
  2. To perform clinically relevant and practice-oriented research on local infectious diseases
  3. To incorporate a culture of research into infectious disease and microbiology clinical practice in Singapore

We welcome collaboration among all hospitals, academic centres and research institutes in Singapore, as well as regionally and internationally.

Research projects

  1. A-KLASS
    A randomised study to compare the efficacy of oral ciprofloxacin versus intravenous ceftriaxone for invasive Klebsiella pneumoniae liver abscess
  2. MRSA
    A randomised study to compare the efficacy of intravenous daptomycin versus vancomycin for MRSA bacteraemia with vancomycin MIC≥1.5ug/mL
  3. CAPES
    A prospective observational study of carbapenem-resistant and carbapenemase producing Enterobacteriaceae in Singapore

Research collaborations

We welcome clinical research collaborations that aim to solve clinically relevant and important infectious disease problems. We are interested in investigator-initiated as well as pharmaceutical industry clinical trials.

We currently have ongoing collaborations with Australasian Society for Infectious Diseases (ASID) Clinical Research Network (CRN) on:

  1. MERINO
    A randomised study to compare the efficacy of intravenous piperacillin-tazobactam versus meropenem for ceftriaxone non-susceptible Escherichia coli and Klebsiella spp. bacteraemia
  2. CAMERA2
    A randomised study to compare the efficacy of intravenous daptomycin or vancomycin plus a beta-lactam versus daptomycin or vancomycin for MRSA bacteraemia

Our investigators

Associate Professor TAN Thuan Tong is head of infectious diseases at Singapore General Hospital with a long-standing research interest in gram negative bacterial resistance.

Dr Shirin KALIMUDDIN is the principal investigator for the MRSA study and site principal investigator at Singapore General Hospital for SCRN.

Associate Professor Andrea KWA is a principal research pharmacist and clinician scientist at Singapore General Hospital and Duke Graduate Medical School, National University of Singapore. Her long-standing research interest is in pharmacokinetic and pharmacodynamic optimisation of antimicrobial agents and extensively drug resistant bacterial infection.

Dr Sophia ARCHULETA is the principal investigator for the A-KLASS study and site principal investigator at National University Hospital for SCRN. She holds a new investigator grant from National Medical Research Council, Singapore for the A-KLASS study. Apart from clinical research interest in infectious diseases, Dr Archuleta is active in postgraduate medical education.

Dr Indumathi VENKATACHALAM is a co-principal investigator for the CAPES study. She is an infectious disease physician and a hospital epidemiologist at National University Hospital.

Dr Kalisvar MARIMUTHU is a co-principal investigator for the CAPES study. He is an infectious disease physician at Tan Tock Seng Hospital. His primary clinical research interest is in infection control.

Event organised

In conjunction with the Courage Fund Infectious Diseases Conference, we have organized a pre-conference workshop on “Clinical Research Network Meeting on Clinical Trials in Bacteraemia” on 11 Mar 2015. The aim of the workshop is to bring together clinicians and researchers who are active in clinical ID research to exchange experiences and ideas on clinical trials in bacteraemia and sow the seed of future collaborations in the Australasian and Asia-Pacific regions. The workshop was well-attended with 50 participants.

Work with us

We are on the lookout for research fellows and assistants. Contact us at email ying_ding@ttsh.com.sg.