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​Positive results from our research will help influence geriatric practice and be translated into clinical practice, thus leading to improved clinical care

IGA's Research aims to develop an interdisciplinary research that spans clinical, behavioural, health services, clinical innovations, healthcare technology assessments, collaborations in basic sciences, as well as less traditional areas of research.

IGA embarks on:

  • Conducting novel ageing research to help in earlier diagnosis and better management of geriatric conditions
  • Innovative models of geriatric care
  • Technological innovations through partnership with various academic and industry partners 

Our Research focus areas include:

  • Ageing Well 
  • Frailty 
  • Ageing Brain 
  • Health Professions Education 

Positive results from our research will help influence geriatric practice and be translated into clinical practice, thus leading to improved clinical care.

Ageing-well.png

With the population of older persons above 65 years old nearly tripling and crossing the 900,000 mark by 2030, ageing-in-place and active ageing have been key focuses in recent years.

With this impressive gain in life expectancy in Singapore, we are interested to look not only at lifespan, but also health span of older persons.

We welcome you to write to us for further potential collaboration / partnership.


Sarcopenia is the degenerative loss of skeletal muscle mass associated with ageing.

sarcopenia.png

Progressive decline in muscle mass of older persons is almost invariable, from as early as 40 years old. A subset of older persons may develop severe functional impairment consequent to sarcopenia.

The need for better characterization to identify the older person at risk of accelerated / pathological sarcopenia and its complications for future interventions resulted in IGA’s brainchild study in sarcopenia –GERILABS!

GERILABS.pngGERILABS – Longitudinal Assessment of Biomarkers for characterisation of early Sarcopenia and predicting frailty and functional decline in community-dwelling Asian older adults Study.

GERILABS serves as IGA’s pivotal longitudinal study in sarcopenia to develop a clinical/ biomarker phenotype for prediction of frailty and functional decline in community-dwelling older adults.

Subjects were recruited from the Centre of Geriatric Medicine (our outpatient geriatric clinic), senior activity centres, family service centres and community centres in the central region.

We also express our heartiest congratulations to Dr Laura Tay,Laura Tay.png our Co-Principal Investigator, for clinching the Gold award in the Singapore Young Investigator Award – Clinical Research category of the 2014 Singapore Health & Biomedical Congress for her work on “Inflammation and the Interaction between Anabolic-Catabolic Pathways in Sarcopenia”.

GERILAB Recruitment Sites

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GERILABS Awards

  1. Outstanding Abstract Oral Presentation
    Adjunct A/Prof Lim Wee Shiong
    Construct and predictive validity of SARC-F as a risk assessment community screening tool for sarcopenia.
    Australian and New ZealandSociety for Sarcopenia and Frailty Research 2017. Adelaide, Australia.
  2. Young Investigator Award
    Dr Yang Yuxin
    MRI estimation of Intermuscular Fat Density in Thigh in a Sarcopenia Population correlation with physical Performance.
    Radiology Asia 2017. Singapore.
  3. Best Poster Award (Bronze)
    Ms Suzanne Yew
    Examining the Impact of Nutrition on Physical Performance and Sarcopenia in Functionally Independent Community-Dwelling Older Adults.
    Asia Pacific Geriatrics Conference 2016. Singapore.
  4. Young Investigator Award – Clinical Research (Gold)
    Dr Laura Tay
    Inflammation and the Interaction between Anabolic-Catabolic Pathways in Sarcopenia.
    Singapore Health & Biomedical Congress 2014. Singapore.

GERILABS Publications

  1. Lim WS, Tay L, Yeo A, Yew S, Ismail NH and Ding YY. (2018). Modulating Effect of Contextual Factors on Factor Structure and Reliability of SARC-F.Journal of the American Medical Directors Association. (DOI: 10.1016/j.jamda.2018.02.009)
  2. Yang YX, Chong MS, Lim WS, Tay L, Yew S, Yeo and Tan CH. (2017). Validity of estimating muscles and fat volume from single MRI slice in older adults with sarcopenia and sarcopenic obesity.Clinical Radiology, 72(5), pp.427.e9-427.e14.
  3. Yang YX, Chong MS, Tay L, Yew S, Yeo A and Tan CH (2016). Automated Assessment of Body Components Using Machine Learning for Dixon Magnetic Resonance Images of Thigh.Magnetic Resonance Materials in Physics, Biology and Medicine, 29(5), pp.723–731.
  4. Tay L, Ding YY, Leung BP, Ismail NH, Yeo A, Yew S, Tay K, Tan C and Chong MS. (2015). Sex-specific differences in risk factors for sarcopenia amongst community-dwelling older adults.AGE, 37, pp.121.
  5. Lim JP, Leung BP, Ding YY, Tay L, Ismail NH, Yeo A, Yew S and Chong MS, 2015. Monocyte chemoattractant protein-1: a proinflammatory cytokine elevated in sarcopenic obesity.Clinical interventions in aging,10, p.605-609.
  6. Chong MS, Tay L, Ismail NH, Tan CH, Yew S, Yeo A, Ye R, Leung B and Ding YY. (2015). The Case for Stage-Specific Frailty Interventions Spanning Community Aging to Cognitive Impairment.Journal of the American Medical Directors Association, 16(11), pp.1003.e13-1003.e19.

GERILABS Conference Presentations

  1. SARC-F and Anthropometric Measures: Enhancing Sarcopenia Screening in Clinical Practice.
    International Conference on Frailty & Sarcopenia Research 2018. Miami Beach, USA
    (Oral category: Adjunct A/Prof Lim Wee Shiong)
  2. Defining a validated cutoff for pre-sarcopenia for risk assessment among community dwelling older persons
    International Conference on Frailty & Sarcopenia Research 2018. Miami Beach, USA
    (Poster category: Adjunct A/Prof Lim Wee Shiong)
  3. Gender-specific Risk Factors for Sarcopenia Progression in Community-Dwelling Older Adults.
    International Conference on Frailty & Sarcopenia Research 2018. Miami Beach, USA
    (Poster category: Dr Laura Tay)
  4. Sarcopenia, but not Frailty Predicts Falls in Well Older Adults with Diabetes
    International Conference on Frailty & Sarcopenia Research 2018. Miami Beach, USA
    (Poster category: Delwyn Lim, Medical student)
  5. Baseline Body Mass Index and Physical Activity Predicts 2-year Sarcopenia Progression in Community-Dwelling Older Adults: The GERI-LABS study.
    International Conference of Frailty and Sarcopenia Research 2017, Barcelona, Spain
    (Poster category: Adjunct A/Prof Lim Wee Shiong)
  6. SARC-F: Defining a validated cutoff for pre-sarcopenia for risk assessment among community dwelling older persons.
    Australian and New Zealand Society for Sarcopenia and Frailty Research 2017. Adelaide, Australia.
    (Poster category: Adjunct A/Prof Lim Wee Shiong)
  7. Construct and predictive validity of SARC-F as a risk assessment community screening tool for sacropenia
    Australian and New Zealand Society for Sarcopenia and Frailty Research 2017. Adelaide, Australia.
    (Poster category: Adjunct A/Prof Lim Wee Shiong)
  8. Baseline Body Mass Index and Physical Activity Predicts 2-year Progression in Sarcopenia.
    The Australian Association of Gerontology 2017. Perth, Australia
    (Poster category: Adjunct A/Prof Lim Wee Shiong)
  9. Combined impact of sarcopenia and frailty on physical function, cognition, and activity level in the community dwelling elderly.
    3rd Asian Conference for Frailty and Sarcopenia 2017. Korea
    (Poster category: Dr Raphael Lee)
  10. Magnetic resonance imaging estimates of intermuscular fat density in the thigh in sarcopenia population: correlation with physical performances
    International Society for Magnetic Resonance in Medicine 2017. Hawaii, USA
    (Poster category: Dr Yang Yuxin)
  11. Validity of estimating subcutaneous and visceral fat volume from single MRI slice in older adults with sarcopenia and sarcopenic obesity.
    International Society for Magnetic Resonance in Medicine 2017. Hawaii, USA
    (Poster category: Dr Yang Yuxin)
  12. Longitudinal Changes in Nutritional Status; Sarcopenia Progression in Community-Dwelling Older Adult.
    21st International Association of Gerontology and Geriatrics World Congress 2017. San Francisco, USA
    (Poster category: Ms Suzanne Yew)
  13. Trends and Predictors of 2-year Activity Participation in Community Dwelling Older Adults.
    21st International Association of Gerontology and Geriatrics World Congress 2017. San Francisco, USA
    (Poster category: Ms Audrey Yeo)
  14. Physical Performance Beyond Muscle Mass in Cognitively Impaired Older Adults: Influence of Insulin-like Growth Factor-1 and Nutrition on Muscle Quality.
    International Conference of Frailty and Sarcopenia Research 2016. Philadelphia, USA
    (Poster category: Dr Laura Tay)
  15. Preserved Functional Performance Despite Loss of Muscle Mass: Muscle Quality Matters.
    Singapore Health and Biomedical Congress 2016. Singapore
    (Poster category: Nadine Foo, Medical student)
  16. Quantification of Muscle and Fat Volumes in Dixon MRI of Thigh with Extreme Learning Machine.
    10th International Association of Gerontology and Geriatrics (IAGG) Asia/Oceania Regional Congress 2015. Chiangmai, Thailand
    (Oral category: Dr Yang Yuxin)
  17. Dixon MRI with Extreme Learning Machine measures muscle and fat tissue volumes
    RadiologyAsia 2015. Singapore
    (Poster category: Dr Yang Yuxin)
  18. Assessment of Adipose Tissue and Muscle Content Using Extreme Learning Machine for Dixon Magnetic Resonance Images of Thigh.
    Singapore Health and Biomedical Congress 2015. Singapore
    (Poster category: Dr Yang Yuxin)
  19. Metabolic Syndrome (MetS) and its association with Sarcopenic Obesity (SO).
    10th International Association of Gerontology and Geriatrics (IAGG) Asia/Oceania Regional Congress 2015. Chiangmai, Thailand
    (Poster category: Amanda Chong, Medical student)
  20. Examining the Impact of Nutrition on Physical Performance and Sarcopenia in Functionally Independent Community-Dwelling Older Adults.
    10th International Association of Gerontology and Geriatrics (IAGG) Asia/Oceania Regional Congress 2015. Chiangmai, Thailand
    (Poster category: Ms Suzanne Yew)
  21. Light Daily Physical Activity as a Potentially Modifiable Determinant of Sarcopenia in community dwelling older adults.
    10th International Association of Gerontology and Geriatrics (IAGG) Asia/Oceania Regional Congress 2015. Chiangmai, Thailand
    (Poster category: Ms Audrey Yeo)
  22. Influence of Nutrition on Physical Performance and Sarcopenia in Functionally Independent community-dwelling older adults.
    Singapore Health and Biomedical Congress 2015. Singapore
    (Poster category: Ms Suzanne Yew)
  23. Light Daily Physical Activity as a Potentially Modifiable Determinant of Sarcopenia in community dwelling older adults.
    Singapore Health and Biomedical Congress 2015. Singapore
    (Poster category: Ms Audrey Yeo)
  24. Monocyte chemoattractant protein-1 (MCP-1): A pro-inflammatory cytokine elevated in sarcopenic obesity (SO).
    67th Gerontological Society of America Annual Scientific Meeting 2014. Washington, DC
    (Poster category: Dr Chong Mei Sian)
  25. Sarcopenic obesity (SO): Consideration of fat mass beyond lean muscle in functional performance limitations in older adults.
    Singapore Health and Biomedical Congress 2014. Singapore
    (Oral category: Dr Chong Mei Sian)
  26. Inflammation and the Interaction between Anabolic-Catabolic Pathways in Sarcopenia.Singapore Health and Biomedical Congress 2014. Singapore
    (Oral category: Dr Laura Tay)

GERILABS Media Updates

Experts call for greater awareness of sarcopenia among elderly (22 Aug TODAY pg 22)

Article inTODAYpaper discussed sarcopenia, the progressive loss of skeletal muscle in the ageing process that is often linked to frailty, a common geriatric syndrome that puts a person at greater risk of falls.Dr Lim Wee Shiong, Senior Consultant, Institute of Geriatrics and Active Ageing (IGA)noted that sarcopenia is not as widely recognized as a geriatric syndrome compared to dementia and falls, and said: "It is thus imperative to raise awareness about sarcopenia and what can be done to prevent or delay the onset of sarcopenia."

An ongoing local study by IGA has found that 25 percent of participants were found to be sarcopenic, and more likely at risk of malnutrition. Dr Lim noted that the 7 percent who were at risk of malnutrition were also 2.4 times more likely to have sarcopenia. He added that while no definitive figures on local prevalence are available, estimates based on the Asian Working Group for Sarcopenia criteria indicated that between 4.1 and 11.5 percent of the older population in Asian countries have sarcopenia. While frailty can be delayed by regular physical exercise and proper nutrition from a younger age, it is not easy to screen for, diagnose, and treat elderly patients for a condition that is still under study. Dr Lim added that the diagnosis of sarcopenia is often not incorporated into routine care of the elderly, as formal diagnosis requires fairly elaborate investigations.

Frailty research also explores the correlations of cognition and frailty. We study the inter-relationship between 2 geriatric giants – Cognition and Frailty.

Cognition-and-frailty.png

Our ongoing studies seek to provide further insight into the distinct yet related entities of frailty and cognitive impairment, including exploring the pathophysiology of frailty in the cognitively impaired older adult.

Oral/Poster Presentations

  • Oral presentation for Society for Geriatric Medicine Biennial Scientific Meeting 2013. Prevalence of frailty phenotype and frailty subdomains amongst a group of community dwelling older adults with mild cognitive impairment (MCI) and mild-moderate Alzheimer's disease (AD).(Dr Lim JP)
  • Poster presentation at AAIC 2014 (Copenhagen, Denmark). Frailty transitions over 6 months in relation to cognitive status in community-dwelling older adults in a tertiary Memory Clinic setting (Dr Chong MS)
  • Oral presentation at ICFSR 2015 (Boston, USA). Frailty transitions over 12-month period in relation to cognitive status in community-dwelling older adults with cognitive impairment attending a Tertiary Memory Clinic (Dr Chong MS)
  • Poster Presentation at ICFSR 2015 (Boston, USA). The Independent Role of Inflammation in Physical Frailty among Older Adults with Mild Cognitive Impairment and Mild-to-Moderate Alzheimer's (Dr Laura Tay)

Publications

  1. Chong MS, Tay L, Chan M, Lim WS, Ye R, Wong WC, Lim JP, Tan EK, Ding YY. Stage-specific relationship between frailty and cognitive impairment. J Frailty Aging 2014; 3(2):113-119.
  2. Chong MS, Tay L, Chan M, Lim WS, Ye R, Ding YY Prospective longitudinal studyof Frailty transitionsin a community-dwelling cohort of older adults with cognitive impairment. BMC Geriatrics (accepted)
  3. Tay L, Lim WS, Chan M, Ye R, Chong MS. The Independent Role of Inflammation in Baseline Physical Frailty Among Older Adults with Mild Cognitive Impairment and Mild-to-Moderate Alzheimer's Disease. JNHA 2015 10.1007/s12603-015-0617-6
  4. Chong MS, Tay L, Ismail NH, Tan CH, Yew S, Yeo A, Ye R, Leung B, Ding YY. The case for potential stage-specific frailty interventions spanning community aging to cognitive impairment. JAMDA 16 (2015) doi.1003.e13e1003.e19

For more publications, please visit our Publications page.

​Models of Care studies are undertaken to seek continual improvement in our clinical services and practice.

  • Frailty and Orthogeriatrics
  • Frailty and Peri-operative geriatrics
  • Frailty in acute and subacute geriatric care settings
  • Frailty and delirium care


​Ageing Brain research, another focus of IGA, is closely associated with our TTSH Cognition and Memory Disorders Service.

Our Ageing Brain studies incorporate:

With the expected exponential increase in dementia patients globally, dementia has received much attention from world leaders other than researchers.

While the quest for a cure remains a main concern, another major challenge is to improve the care and lives of dementia patients and their caregivers.

Apart from diagnostic and translational studies, clinician researchers at IGA have embarked on studies that look into care integration, quality of life, caregiver burden and advanced care planning in early dementia.

We also have a large clinical database being one of the largest tertiary memory clinics locally.

Delirium – a serious disturbance in a person's mental abilities that results in a decreased awareness of one's environment and confused thinking – is common among hospitalised older patients.

To combat delirium in older patients, TTSH Geriatric Medicine set up the Geriatric Monitoring Unit (GMU), a specialised 5-bed ward to reside and render more focused care for older delirious patients. GMU incorporates an elderly-friendly design with lower staff-patient ratio, coupled with structured interventions and bright light therapy.

The new model of delirium care is the first of its kind internationally, and has seen much positive results with many patients making quicker recoveries.

Our Publications

  1. Chong MS, Chan PCM, Kang J, Han HC, Ding YY, Tan TL. A New Model of Delirium Care in the acute geriatric setting: Geriatric Monitoring Unit. BMC Geriatrics 2011,11:41. doi:10.1186|1471-2318-11-41.
  2. L Tay, M Chan, Chong MSPotential for Functional Recovery Following Delirium in Older Adults with Dementia: Impact of a Multi-component Delirium Management Program. J Hosp Med. 2013 Jun; 8(6):321-7. doi: 10.1002|jhm.2035. Epub 2013 Mar 29.
  3. Chong MS, Tan KT, Tay L, Chan M, Wong YM, Ancoli-Israel S. Bright light therapy as part of a multi-component management improves sleep, cognitive and functional outcomes in delirious older hospitalised adults. Clin Interv Aging. 2013:8:565-72. doi: 10.2147|CIA.S44926. Epub 2013 May 22.
  4. Chong MS, Chan M, Tay L, Ding YY. Outcomes of a Specialized Delirium Management Unit in an acute geriatric care setting: The Geriatric Monitoring Unit (GMU). Clin Interv Aging 2014:9:603-612.
  5. Lam CY, Tay L, Chan M, Ding YY, Chong MS. Prospective observational study of delirium recovery trajectories and associated short-term outcomes in older adults admitted to a specialized delirium unit. . J Am Geriatr Soc 2014 Sep;62(9):1649-1657. doi: 10.1111|jgs.12995.
  6. Chong E, Tay L, Chong MS. Phenomenological differences in delirium symptoms among patients with existing dementia (DsD) versus those without dementia (DaD) admitted to the Geriatric Monitoring Unit (GMU): cognitive and non-cognitive symptoms. Int Psychogeriatrics 2015. Jun 9:1-11. http://dx.doi.org/10.1017/S1041610215000770 




​Health Professions Education (HPEd) refers to the spectrum of educational activities that prepare healthcare professionals (including doctors, nurses, and allied-health professionals) for practice and continuous professional development. 

With the rapidly aging population and the increasing complexity of the healthcare system in Singapore, it is imperative that healthcare professionals are capable of delivering integrated, team-based and patient-centred care to enable optimal health outcomes.

IGA is dedicated to advancing health professions education and practice through research. Areas of focus include interprofessional education & collaborative practice, qualitative and mixed methods research, innovations in curriculum & pedagogy, and evidence-based medicine in the elderly.

Our overarching goal is to engage in good quality and relevant research using a plurality of methods to ultimately answer the holy grail question of "What improvements in health professions education will lead to better health for individuals and populations?"


Chan E. Y., Glass G., Chua K. C., Ali N. and Lim W. S. (2018) 'Relationship between Mastery and Caregiving Competence in Protecting against Burden, Anxiety and Depression among Caregivers of Frail Older Adults', J Nutr Health Aging, 22(10), pp. 1238-1245 
Chong E., Chan M., Lim W. S. and Ding Y. Y. (2018) 'Frailty Predicts Incident Urinary Incontinence Among Hospitalized Older Adults-A 1-Year Prospective Cohort Study', J Am Med Dir Assoc, 19(5), pp. 422-427
Chong E., Chan M., Lim W. S. and Ding Y. Y. (2018) 'Response to the Letter to the Editor: Flaws Related to the Article Entitled "Frailty Predicts Incident Urinary Incontinence Among Hospitalized Older Adults"', J Am Med Dir Assoc, 19(11), pp. 1020-1021 
Chong E., Ho E., Baldevarona-Llego J., Chan M., Wu L., Tay L., Ding Y. Y. and Lim W. S. (2018c) 'Frailty in Hospitalized Older Adults: Comparing Different Frailty Measures in Predicting Short- and Long-term Patient Outcomes', J Am Med Dir Assoc, 19(5), pp. 450-457.e3
Chong M. S., Tan C. N., Yew S., Lim J. P., Lim W. S. and Lieu P. K. (2018) 'Successful Ageing in Nonagenarians: Bio-psychosocial Factors Determining Successful Ageing in Long-Lived Older Adults', J Am Med Dir Assoc, 19(1), pp. 90-92 
Declarador N., Ramason R., Tay L., Chan W. L. W. and Kwek E. (2018) 'Beyond comanaged inpatient care to community integration: Factors leading to surgical delay in hip fractures and their associated outcomes', J Orthop Surg (Hong Kong), 26(2), pp. 2309499018783909
Gao Q., Gwee X., Feng L., Nyunt M. S. Z., Collinson S. L., Chong M. S., Lim W. S., Lee T. S., Yap P., Yap K. B. and Ng T. P. (2018) 'Mild Cognitive Impairment Reversion and Progression: Rates and Predictors in Community-Living Older Persons in the Singapore Longitudinal Ageing Studies Cohort', Dement Geriatr Cogn Dis Extra, 8(2), pp. 226-237 
Kua J., Chan M., See J., Ng D. and Lim W. S. (2018) 'STarDom study - Applying systems theory framework for Internal Medicine senior residency career development in a Singapore ACGMEI Residency Programme' TAPS, 3(2), pp. 6-18
Lau S., Ali N., Lim J. P. and Lim W. S. (2018) 'ZBI multidimensionality: The salience of worry about performance', Int Psychogeriatr, pp. 1-3 
Li J., Cesari M., Del Campo N., Andrieu S., Dong B., Lim W. S. and Vellas B. (2018) 'Impact of diabetes on caregiver stress in patients with Alzheimer's disease: data from the ICTUS study', Int Psychogeriatr, 30(8), pp. 1109-1117
Li R., Chong M. S., Chan M., Tay L., Ali N.. and Lim W. S. (2018) 'Worry About Caregiving Performance: A Confirmatory Factor Analysis', Front Med (Lausanne), 5, pp. 79 
Liaw S. Y., Carpio G. A. C., Lau Y., Tan S. C., Lim W. S. and Goh P. S. (2018) 'Multiuser virtual worlds in healthcare education: A systematic review', Nurse Educ Today, 65, pp. 136-149
Lim J. P., Chong M. S., Tay L., Yang Y. X., Leung B., Yeo A., Yew S., Tan C. H. and Lim W. S. (2018) 'Inter-muscular adipose tissue is associated with adipose tissue inflammation and poorer functional performance in central adiposity', Arch Gerontol Geriatr, 81, pp. 1-7 
Lim W. S., Canevelli M. and Cesari M. (2018) 'Editorial: Dementia, Frailty and Aging', Front Med (Lausanne), 5, pp. 168
Lim W. S., Tay L., Yeo A., Yew S., Hafizah N. and Ding Y. Y. (2018) 'Modulating Effect of Contextual Factors on Factor Structure and Reliability of SARC-F', J Am Med Dir Assoc, 19(6), pp. 551-553 
Loo M. E., Krishnasamy C. and Lim W. S. (2018) 'Considering Face, Rights, and Goals: A Critical Review of Rapport Management in Facilitator-Guided Simulation Debriefing Approaches', Simul Healthc, 13(1), pp. 52-60
Malhotra R., Bautista M. A. C., Muller A. M., Aw S., Koh G. C. H., Theng Y. L., Hoskins S. J., Wong C. H., Miao C., Lim W. S., Malhotra C. and Chan A. (2018) 'The Aging of a Young Nation: Population Aging in Singapore', Gerontologist. doi: 10.1093/geront/gny160 
Tay L., Leung B., Wee S., Tay K. S., Ali N., Chan M. and Lim W. S. (2018) 'Association of nutrition and immune-endocrine dysfunction with muscle mass and performance in cognitively impaired older adults', Arch Gerontol Geriatr, 75, pp. 20-27.
Wong J., Archarya. R., Mok K. H, Tham K. Y, Tan E, Ting J, Lim W. S (2018) 'SimRound, A novel approach to transitions of Junior Medical Students into Clinical Clerkships: Rationale, Development and Lessons Learnt', MedEdPublish, 7, pp. 40. 


Lim WS, Tham KM, Adzhahar FBB, Neo HY, Wong WC and Ringsted C. (2017). Determinants of clarification research purpose in medical education research: a systematic review. The Asia Pacific Scholar, 2(2), pp.8-17 
Feng L, Nyunt MS, Gao Q, Feng L, Lee TS, Tsoi T, Chong MS, Lim WS, Collinson S, Yap P, Yap KB and Ng TP. (2017). Physical frailty, cognitive Impairment and the risk of dementia in the Singapore Longitudinal Ageing Studies (SLAS). The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 72(3), pp.369-375
Feng L, Lim WS, Chong MS, Lee TS, Gao Q, Nyunt MS, Feng L, Kua EH and Ng TP. (2017). Depressive Symptoms Increase the Risk of Mild Neurocognitive Disorders among Elderly Chinese. The Journal of Nutrition, Health and Aging, 21(2), pp.161-164 
Chong E, Ho E, Baldevarona-Llego J, Chan M, Wu L, Tay L, Ding YY and Lim WS. (2017). Frailty in Hospitalized Older Adults: Comparing Different Frailty Measures in Predicting Short- and Long-term Patient Outcomes. Journal of the American Medical Directors Association, 8610(17), pp.30580-30587
Chong E, Ho E, Baldevarona-Llego J, Chan M, Wu L and Tay L. (2017). Frailty and Risk of Adverse Outcomes in Hospitalized Older Adults: A Comparison of Different Frailty Measures. Journal of the American Medical Directors Association, 18(7), pp.638.e7-638.e11 
Chew J, Lim WS, Chong MS, Ding YY and Tay L. (2017). Impact of frailty and residual subsyndromal delirium on 1-year functional recovery: A prospective cohort study. Geriatrics and Gerontology International, 17(12), pp.2472-2478
Ding YY. (2017). Predictive Validity of Two Physical Frailty Phenotype Specifications Developed for Investigation of Frailty Pathways in Older People. Gerontology, 63, pp.401-410  
Ding YY, Kuha J and Murphy M. (2017). Multidimensional predictors of physical frailty in older people: identifying how and for whom they exert their effects. Biogerontology, 18(2), pp.237-252
Ding YY, Kuha J and Murphy M. (2017). Pathways from physical frailty to activity limitation in older people: Identifying moderators and mediators in the English Longitudinal Study of Ageing. Experimental Gerontology, 98, pp.169-176 
Chong MS, Lim JP, Tan CN, Yew S, Lim WS and Lieu PK. (2017). Successful ageing in nonagenarians: bio-psychosocial factors determining successful ageing in long-lived older adults. Journal of the American Medical Directors Association, 19(1), pp.90-92
Feng L, Nyunt MSZ, Gao Q, Feng L, Lee TS, Tsoi T, Ching MS, Lim WS, Collinson S, Yap P, Yap KB and Ng TP (2017). Physical frailty, cognitive impairment and the risk of neurocognitive disorder in the Singapore Longitudinal Ageing Studies (SLAS). Journal of the American Medical Directors Association, 18(3), pp.252-258 
Rawtaer I, Gao Q, Nyunt MSZ, Feng L, Chong MS, Lim WS, Lee TS, Yap P, Yap KB and Ng TP. (2017). Psychosocial Risk and Protective Factors and Incident Mild Cognitive Impairment and Dementia in Community Dwelling Elderly: Findings from the Singapore Longitudinal Ageing Study. American Journal of Alzheimers Disease and Other Dementias, 57(2), pp.603-611
Heywood R, Gao Q, Nyunt M, Feng L, Chong MS, Lim WS, Yap P, Lee T, Yap KB, Wee SL and Ng TP. (2017). Hearing loss and risk of mild cognitive impairment and dementia: Findings from the Singapore Longitudinal Ageing Study. Dementia and Geriatric Congitive Disorders, 43(5-6), pp.259-268 
Chng A, Yong K, Ng D, Heyzer L and Lim WS. (2017). Trends in geriatrics-related translational research and funding in the big 4 medical journals. Journal of the American Medical Directors Association, 18(6), pp.544-545
ZY Koh, SWM Lim and WS Lim. (2017).  An interesting case of "refractory" hypomagnesemia. Journal of the American Medical Directors Association, 18(7), pp.632-633 
Walsh K, Noben C, Gregory S, Lim WS, Green C, Roberts T, Maloney S, liic D, Rivers G and Reeves S. (2017). Cost benefit analysis of healthcare professional education: report of a conference workshop. BMJ Simulation and Technology Enhanced Learning, pp.bmjstel-2017-000214
Dent E, Lien C, Lim WS, Wong WC, et al. (2017). The Asia-Pacific Clinical Practice Guidelines for the Management of Frailty. Journal of the American Medical Directors Association, 18(7), pp.564-575 
Nyunt MSZ, Soh CY, Qi G, Gwee X, Ling ASL, Lim WS, Lee TS, Yap PSL, Yap KB and Ng TP. (2017). Characterisation of Physical Frailty and Associated Physical and Functional Impairments in Mild Cognitive Impairment. Frontiers in Medicine, 18(4), pp.230
Tay L, Leung BPL, Wee S, Tay K, Ali N, Chan M and Lim WS. (2017). Association of nutrition and immune-endocrine dysfunction with muscle mass and performance in cognitively impaired older adults. Archives of Gerontology and Geriatrics, 75, pp.20-27 
Lim WS, Wong SF, Leong I, Choo P and Pang WS. (2017). Forging a Frailty-Ready Healthcare System to Meet Population Ageing. International Journal Environmental Research and Public Health, 14(12), pp.E1448
Yang YX, Chong MS, Lim WS, Tay  L, Yew S, Yeo and Tan CH. (2017). Validity of estimating muscles and fat volume from single MRI slice in older adults with sarcopenia and sarcopenic obesity. Clinical Radiology, 72(5), pp.427.e9-427.e14 
Teo WL, Lee MCL and Lim WS. (2017). The relational activation of resilience model: How leadership activates resilience in an organizational crisis. Journal of Contingencies and Crisis, 25, pp.136–147
Ong Y, Tan N, Knab MS, Farrell SE and Lim WS. (2017). Attitudes of clinician educators towards interprofessional education and collaboration: Insights from two interprofessional scales. Journal of Interprofessional Care, 1(5), pp.656-660 
Yock Y, Lim I, Lim YH, Lim WS, Chew N and Archuleta S. (2017). Sometimes Means Some of the Time: Residents' Overlapping Responses to Vague Quantifiers on the ACGME-I Resident Survey. Journal of Graduate Medical Education, 9(6), pp.735-740
Win KK, Chong MS, Ali N, Chan M and Lim WS. (2017). Burden among Family Caregivers of Dementia in the Oldest-Old: An Exploratory Study. Frontiers in Medicine, 22(4), pp.205 
YJ Zhao and WS Lim. (2017). Dabigatran compared with rivaroxaban vs warfarin. JAMA Internal Medicine, 177(5), pp.74
Neo HY, Xu HY, Wu HY and Hum A. (2017). Prediction of Poor Short-Term Prognosis and Unmet Needs in Advanced Chronic Obstructive Pulmonary Disease: Use of the Two-Minute Walking Distance Extracted from a Six-Minute Walk Test. Journal of Palliative Medicine, 20(8), pp.821-828 
A Haider, DS Zhukovsky, Yee CM, J Baidoo, KC Tanco, HA Stewart, T Edwards,
MP Joy, L Kuriakose, Z Lu, JL Williams, DD Liu and E Bruera. (2017). Opioid Prescription Trends Among Patients With Cancer Referred to Outpatient Palliative Care Over a 6-Year Period. Journal of Oncology Practice, 13(12), pp.e972-e981
M Koh, A Hum and WW Xiang. (2017). Clinical Variety May Help Prevent Burnout After a Decade in Palliative Care. Journal of Pain and Symptom Management, 55(2), pp.e3-e5 
Chua KS and Kuah CW. (2017). Innovating With Rehabilitation Technology in the Real World: Promises, Potentials, and Perspectives. American Journal of Physical Medicine & Rehabilitation, 96(10 Suppl 1), pp.S150-S156
Arvaneh M, Guan C, Ang KK, Ward TE, Chua KS, Kuah CW, Joseph GJ, Phua KS and Wang C. (2017). Facilitating motor imagery-based brain-computer interface for stroke patients using passive movement. Neural Computing and Applications, 28(11), pp.3259-3272 
Hussain A, Budhota A, Contu S, Kager S, Vishwanath DA, Kuah CW, Yam LH, Chua KS, Masia L and Campolo D. (2017). Quantitative assessment of motor functions post-stroke: Responsiveness of upper-extremity robotic measures and its task dependence. IEEE International Conference on Rehabilitation Robotics, pp.1037-1042


Tay L,  Lim WS, Chan M, Ali N. and Chong MS (2016).  A combined cognitive stimulation and physical exercise programme (MINDVital) in early dementia: Differential effects on single and dual-task performance. Gerontology, 62(6), pp.604-610. 
Ong YH, Lim I, Tan  KT, Chan M and Lim WS. (2016). Assessing Shared Leadership in Interprofessional Team Meetings: A Validation Study. The Asia Pacific Scholar, 1(1), pp.10-21
Kua J, Ramason R, Ganesan R and Chong MS (2016). Which frailty measure is a good predictor of early post-operative complications in elderly hip fracture patients? Archives of Orthopaedic and Trauma Surgery,136(5), pp.639–647 
Yang YX, Chong MS, Tay L, Yew S, Yeo A and Tan CH (2016). Automated Assessment of Body Components Using Machine Learning for Dixon Magnetic Resonance Images of Thigh. Magnetic Resonance Materials in Physics, Biology and Medicine, 29(5), pp.723–731
Chan CY, Sum MY, Lim WS, Chew NW, Samarasekera DD and Sim K. (2016). Adoption and correlates of Postgraduate Hospital Educational Environment Measure (PHEEM) in the evaluation of learning environments – A systematic review. Medical Teacher, 38(12), pp.1248-1255 
Rawtaer I, Feng L, Yuen VH, Li J, Chong MS, Lim WS, Lee TS, Qiu C, Feng L, Kua EH and Ng TP. (2016). A Risk Score for the Prediction of Neurocognitive Disorders among Community-Dwelling Chinese Older Adults. Dementia and Geriatric Cognitive Disorders, 41(5-6), pp.348-58
Abengaña J, Chong MS and Tay L. (2016). Delirium superimposed on dementia: phenomenological differences between patients with and without behavioral and psychological symptoms of dementia in a specialized delirium unit. International Psychogeriatrics, 29(3), pp.485-495 
Feng L, Chong MS, Lim WS, Gao Q, Nyunt MS, Lee TS, Collinson SL, Tsoi T, Kua EH and Ng TP. (2016). Tea Consumption Reduces the Incidence of Neurocognitive Disorders: Findings from the Singapore Longitudinal Aging Study. The Journal of Nutrition, Health and Aging, 20(10), pp.1002-1009
Ding YY. (2016). Developing physical frailty specifications for investigation of frailty pathways in older people. AGE, 38(2), pp.47 
Boh T, Seetoh L, Tan KT and Tan TL. (2016). Resident Presentation Use of Potentially Inappropriate Medications among Hospitalized Geriatric Patients in a Tertiary Hospital in Singapore. Journal of the American Geriatrics Society, 64, pp.S271–S272
J Chew, S Cheong and L Tay. (2016). Quetiapine-induced cutaneous vasculitis: diagnostic challenges and therapeutic implications. Journal of Amercian Geriatrics Society, 64(5), pp.1137-1138 
Tay L, Lim WS, Chan M, Ye RJ and Chong MS. (2016). The Independent Role of Inflammation in Physical Frailty among Older Adults with Mild Cognitive Impairment and Mild-to-Moderate Alzheimer's Disease. The Journal of Nutrition, Health and Aging, 20(3),pp.288-299


Ding YY, Kader B, Christiansen C and Berlowitz D. (2015). Haemoglobin Level and Hospital Mortality Among ICU Patients With Cardiac Disease Who Received Transfusions. Journal of the American College of Cardiology, 66(22), pp.2510-2518 
Tay L, Ding YY, Leung BP, Ismail NH, Yeo A, Yew S, Tay K, Tan C and Chong MS. (2015). Sex-specific differences in risk factors for sarcopenia amongst community-dwelling older adults. AGE, 37, pp.121
Lim WS and Ding YY. (2015). Evidence-balanced Medicine: "Real" Evidence-based Medicine in the Elderly. Annals of the Academy of Medicine, 44(1), pp.1-5 
Lim JP, Leung BP, Ding YY, Tay L, Ismail NH, Yeo A, Yew S, Chong MS. (2015). Monocyte chemoattractant protein-1: a proinflammatory cytokine elevated in sarcopenic obesity. Clinical Interventions in Aging, 10, pp.605-609
Abisheganaden J, Ding YY, Chong W, Heng B, Verma A and Lim T. (2015). Health-Care Associated Pneumonia (HCAP): Identification of Low and High-Risk Patients.Current Respiratory Medicine Reviews,11(3), pp.241-246 
Goh LK, Lim WS, Teo S, Chan M, Tay L, Ng TP, Vijayaraghavan A, Tan CH, Lee TS and Chong MS. (2015). TOMM40 alterations in Alzheimer's disease over a 2-year follow-up period. Journal of Alzheimer's disease, 44(1), pp.57-61
Ng TP, Feng L, Lim WS, Chong MS, Lee TS, Yap KB, Tsoi T, Liew TM, Collinson S, Kandiah N and Yap P. (2015). Montreal Cognitive Assessment for Screening Mild Cognitive Impairment: Variations in Test Performance and Scores by Education in Singapore. Dementia and Geriatric Cognitive Disorders, 39(3-4), pp.176-185 
Lau S, Chong MS, Ali N, Chan M, Chua KC, Ang YY and Lim WS. (2015). Caregiver burden: Looking beyond the unidimensional total score. Alzheimer Disease & Associated Disorders,29(4), pp.338-346
Chew J, Chong MS, Fong YL and Tay L. (2015). Outcomes of a multimodal cognitive and physical rehabilitation program for persons with mild dementia and their caregivers: a goal-oriented approach. Clinical Interventions in Aging, 22(10), pp.1687-1694 
Chong MS, Tay L, Ismail NH, Tan CH, Yew S, Yeo A, Ye R, Leung B and Ding YY. (2015). The Case for Stage-Specific Frailty Interventions Spanning Community Aging to Cognitive Impairment. Journal of the American Medical Directors Association, 16(11), pp.1003.e13-1003.e19
Loo BKG, Chew J and S Sridevi. (2015). Pilot Programme on Animal-Assisted Therapy in Singapore. SAGE, 24(2), pp.113-116 
Chong MS, Tay L, Chan M, Lim WS, Ye R and Ding YY. (2015).Prospective longitudinal study of frailty transitions in a community-dwelling cohort of older adults with cognitive impairment. BMC Geriatrics, 29(15), pp.175
Koh G, Ling C, Ma B, Chen C, Lim WS, Scherer S, Amin Z and Merchant, R. (2015). Effect of a New Longitudinal Interprofessional Geriatric Medicine Educational Track on Knowledge and Attitude of Medical Students: A Controlled Cohort Study. Journal of the American Geriatrics Society, 63(3), pp.558-564. 
Cheong C, Mechant R, Ngiam N and Lim WS. (2015). Facilitated simulated patient sessions in mental-state examination teaching. Medical Education, 49(11), pp.1147-1148.
Lin L, Lim WS, Zhou H, Khoo A, Tan K, Chew A, Foo D, Chin J and Lim B. (2015). Clinical and Safety Outcomes of Oral Antithrombotics for Stroke Prevention in Atrial Fibrillation: A Systematic Review and Network Meta-analysis. Journal of the American Medical Directors Association, 16(12), pp.1103.e1-1103.e19. 
Seng WR, Belani MH, Ramason R, Naidu G and Doshi HK. (2015). Functional Improvement in Geriatric Hip Fractures: Does Vitamin D Deficiency Affect the Functional Outcome of Patients With Surgically Treated Intertrochanteric Hip Fractures. Geriatric Orthopaedic Surgery & Rehabilitation, 6(3), pp.186-191
Lim JP, Li TZ and Lim WS. (2015). Memantine-Induced Myoclonus Precipitated by Renal Impairment and Drug Interactions. Journal of the American Geriatrics Society, 63(12), pp.2643-2644. 
Veronese N, Cereda E, Solmi, M, Sergi G, Chan M et al. (2015). Inverse relationship between body mass index and mortality in older nursing home residents: a meta-analysis of 19,538 elderly subjects. Obesity Reviews, 16(11), pp.1001-1015
Cheung YB, Xu Y, Feng L, Feng L, Ma SZN, Chong MS, Lim WS, Lee TS, Yap P, Yap KB and Ng TP. (2015). Unconditional and Conditional Standards Using Cognitive Function Curves for the Modified Mini-Mental State Exam: Cross-Sectional and Longitudinal Analyses in Older Chinese Adults in Singapore. The American Journal of Geriatric Psychiatry, 23(9), pp.915-924 
Doshi HK, Ramason R, Azellarasi J, Chan WL and Naidu G. (2014). Functional improvement of self-care in the elderly after hip fracture: is age a factor? Archives of Orthopaedic and Trauma Surgery, 134(4), pp.489-493 
Lim WS, Cheah WK, Ali N, Han HC, Anthony PV, Chan M and Chong MS. (2014). Worry about performance: a unique dimension of caregiver burden. International Psychogeriatrics, 26(4), pp.677-678
Ramason R, Chong MS, Chan W and Rajamoney GN. (2014). Innovations in Hip Fracture Care: A Comparison of Geriatric Fracture Centres. Journal of the American Medical Directors Association, 15(4), pp.232-233 
Chong MS, Chan M, Tay L and Ding YY. (2014). Outcomes of an innovative model of acute delirium care: the Geriatric Monitoring Unit (GMU). Clinical Intervention in Aging, 9, pp.603–612.
Atchley P, Chan M and Gregersen S. (2014). A strategically timed verbal task improves performance and neurophysiological alertness during fatiguing drives.The Journal of the Human factors and Ergonomcs Society, 56(3), pp.453-462 
Tan K, Adzhahar F, Lim I, Chan M and Lim WS. (2014). Transactive memory system as a measure of collaborative practice in a geriatrics team: implications for continuing interprofessional education. Journal of Interprofessional Care, 28(3), pp.239-245
Ramason R, Selvaganapathi N, Ismail NH, Wong WC,  Rajamoney G and Chong MS. (2014). Prevalence of Vitamin D Deficiency in Patients With Hip Fracture Seen in an Orthogeriatric Service in Sunny Singapore. Geriatric Orthopaedic Surgery & Rehabilitation, 5(2), pp.82-86 
Tay L, Chua KC, Lim WS, Chan M, Ang YY, Koh E and Chong MS. (2014). Differential perceptions of quality of life (QoL) in community-dwelling persons with mild-to-moderate dementia. International Psychogeriatrics, 26(8), pp.1273-1282
Chong MS, Tay L, Chan M, Lim WS, Ye R, Wong WC, Lim JP, Tan EK and Ding YY. (2014). Stage-specific relationship between frailty and cognitive impairment. Journal of Frailty and Aging, 3(2), pp.113-119 
Lam CY, Tay L, Chan M, Ding YY and Chong MS. (2014). Prospective observational study of delirium recovery trajectories and associated short-term outcomes in older adults admitted to a specialized delirium unit. Journal of Amercian Geriatrics Society, 62(9), pp.1649-1657
Nyunt M, Chong MS, Lim WS, Lee TS, Yap P and Ng TP. (2013). Reliability and Validity of Clinical Dementia Rating for community-living elderly with no informant. Dementia and Geriatric Cognitive Disorder Extra, 3(1), pp.407-416 
Chong MS, Goh L, Lim WS, Chan M, Tay L, Chen GB, Feng L, Ng TP, Tan CH and Lee TS. (2013). Gene expression profiling of peripheral blood leukocytes shows consistent longitudinal downregulation of TOMM40 in AD subjects and upregulation of PLOD1, SLC2A8, KIR2DL5A in fast Alzheimer's disease (AD)-progressors. Journal of Alzheimer's disease, 34(2), pp.339-405
Feng L, Chong MS, Lim WS, Lee TS, Collinson SL, Yap P and Ng TP. (2013). Metabolic syndrome (MetS) and amnestic mild cognitive impairment (aMCI): findings from a population-based cohort study in Singapore. Journal of Alzheimer's disease, 34(3), pp.649-657 
Tay L, Chan M and Chong MS. (2013). Functional improvement in hospitalized older adults is independent of dementia diagnosis: experience of a specialized delirium management unit. Journal of Hospital medicine, 8(6), pp.321-327
Chong MS, Tan KT, Tay L, Chan M, Wong YM and Ancoli-Israel S. (2013). Bright light therapy as part of a multi-component management improves sleep, cognitive and functional outcomes in delirious older hospitalised adults. Clinical Interventions in Aging, 8: pp.565-572 
Chong MS, Tan WS, Chan M, Lim WS, Ali N, Ang YY and Chua KC. (2013). Cost of informal care for community-dwelling mild to moderate dementia patients in a developed Southeast Asian country. International Psychogeriatrics, 25(9), pp.1475-1483
Ting SK, Chong MS, Kandiah N, Hameed S, Tan L, Au WL, Prakash KM, Pavanni R, Lee TS, Foo JN, Bei JX, Yu XQ, Liu JJ, Zhao Y, Lee WL and Tan EK. (2013). Absence of A673T APP variant in Asian Alzheimer's Disease & Population. Neurobiology of Ageing, 34(10), pp.2441.e7-8 
Nagaendran K, Chen LH, Chong MS, Chua EV, Goh CK, Kua J, Lee T, Lim WS, Marziyana AR, Ng CC, Ng LL, Seow D, Sitoh YY, Yap LK and Yeo D. (2013). Ministry of health Clinical Practice Guidelines: Dementia. Singapore Medical Journal, 54(5), pp.293-299
Neo HY, Tan KT and Ding YY. (2013). Higher than expected rates of seizures associated with the use of ertapenem in older hospitalized patients. Journal of Clinical Gerontology & Geriatrics, 4(1), pp.17-21. 
Ding YY, Abisheganaden, Chong WF, Heng BH and Lim TK. (2013). Effectiveness of acute geriatric units in the real world: The case of short-term mortality among seniors hospitalized for pneumonia. Geriatrics & Gerontology International, 13(1), pp.55-62
Doshi HK, Ramason R, Azellarasi J, Naidu G and Chan WL. (2013). Orthogeriatric model for hip fracture patients in Singapore: our early experience and initial outcomes. Archives of Orthopaedic and Trauma Surgery, 134(3), pp.351-357 


Special Issue: Dementia, Frailty and Aging

Welcome to this issue under Frontiers in Medicine which blends nicely with our research focuses of ageing brain (dementia) and frailty. This collection of 14 articles runs the gamut from insights in interface between cognition and physical domains, through to pertinent areas of caregiving and diagnosis in dementia, and evolving areas such as big data and microbes theory in brain ageing.

Find out more about the articles from here:

https://www.frontiersin.org/research-topics/5609/dementia-frailty-and-aging

https://www.frontiersin.org/articles/10.3389/fmed.2018.00168/full

https://www.frontiersin.org/research-topics/5609/dementia-frailty-and-aging#articles
















2019/06/13
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