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GeriLABS, the acronym for our study titled “Longitudinal Assessment of Biomarkers for characterisation of early Sarcopenia and predicting frailty and functional decline in community-dwelling Asian older adults”, aims to develop a clinical/biomarker phenotype for the prediction of frailty and functional decline in community-dwelling older adults.

Started since 2013, we recruited older participants from the community to undergo a series of clinical and physical assessments, imaging scans and blood tests over a span of 5 years. 

With the successful conclusion of our first phase in 2018, the team organised appreciation forums for our participants and community partners to share about the study findings alongside strategies for the prevention of sarcopenia and sarcopenic obesity.

Our Landmark Study

A firm believer of giving back to the community, these get-togethers allowed our deepest gratitude to the participants, for their trust and time journeying with us. We also lauded their spirit of giving back to the society for medical advancements, including three nonagenarian participants aged 92-98 years old.

Following the success of GeriLABS, we embarked on our second wave (GeriLABS 2) in December 2017, studying the interplay of bones, muscles and fats.

Our GeriLABS 1 and 2 studies have created a strong foothold in raising awareness of sarcopenia and frailty, and more recently, osteosarcopenic obesity. Following through our Asian cohorts of community-dwelling older adults, we are excited to push the frontiers of knowledge and contribute to future developments in this emerging field.

Find out more about our study team and accolades below:

Prof Lim Wee Shiong
Prof Lim Wee Shiong
 A Prof Ding Yew Yong
 A Prof Ding Yew Yong
Dr Justin Chew
Dr Justin Chew
Dr Lim Jun Pei
Dr Lim Jun Pei
Dr Noor Hafizah Bte Ismail
Dr Noor Hafizah Bte Ismail
Dr Laura Tay
Dr Laura Tay
A Prof Tan Cher Heng
A Prof Tan Cher Heng
A Prof Gervais Wan
A Prof Gervais Wan
Dr Ankit Tandon
Dr Ankit Tandon
Dr Alvin Tan
Dr Alvin Tan
Dr Goh Liuh Ling
Dr Goh Liuh Ling
Dr Chan Siew Pang
Dr Chan Siew Pang
A Prof Dr Fabian Lim
A Prof Dr Fabian Lim
Kalene Pek
Kalene Pek
Audrey Yeo
Audrey Yeo
Suzanne Yew
Suzanne Yew
Tan Cai Ning
Tan Cai Ning




Lim WS, Lim JP, Chew J, Tan AWK. Calf Circumference as a Case-Finding Tool for Sarcopenia: Influence of Obesity on Diagnostic Performance. Journal of the American Medical Directors Association. 2020.
Lim WS, Lim JP, Chew J, Tan A. Influence of Obesity on Diagnostic Accuracy and Optimal Cutoffs for Sarcopenia Screening in Non-Frail Older Adults: A Comparison of SARC-F Versus SARC-CalF. The Journal of Nutrition, Health and Aging. 2020.
Chew J, Yeo A, Yew S, Lim JP, Tay L, Ding YY, Lim WS. Muscle Strength Definitions Matter: Prevalence of Sarcopenia and Predictive Validity for Adverse Outcomes Using the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) Criteria. The Journal of Nutrition, Health and Aging. 2020;24(6):614-8.
Lim WS, Chew J, Lim JP, Tay L, Hafizah N, Ding YY. Case for Validated Instead of Standard Cut-Offs for SARC-CalF. The Journal of Nutrition, Health and Aging. 2019;23(4):393-5.
Lim JP, Chong MS, Tay L, Yang YX, Leung BP, Yeo A, …, Lim WS. Inter-muscular adipose tissue is associated with adipose tissue inflammation and poorer functional performance in central adiposity. Archives of Gerontology and Geriatrics. 2019;81:1-7.
Khor E, Lim JP, Tay L, Yeo A, Yew S, Ding YY, Lim WS. Obesity Definitions in Sarcopenic Obesity: Differences in Prevalence, Agreement and Association with Muscle Function. The Journal of frailty & aging. 2019.
Chew J, Tay L, Lim JP, Leung BP, Yeo A, Yew S, Ding YY, Lim WS. Serum Myostatin and IGF-1 as Gender-Specific Biomarkers of Frailty and Low Muscle Mass in Community-Dwelling Older Adults. The Journal Nutrition Health Ageing. 2019;23(10):979-86.
Lim WS, Tay L, Yeo A, Yew S, Hafizah N, Ding YY. Modulating Effect of Contextual Factors on Factor Structure and Reliability of SARC-F. Journal of the American Medical Directors Association. 2018;19(6):551-3.
Lim JP, Chong MS, Tay L, Yang YX, Leung BP, Yeo A, …, Lim WS. Inter-muscular adipose tissue is associated with adipose tissue inflammation and poorer functional performance in central adiposity. Archives of Gerontology and Geriatrics. 2018;81:1-7.
Yang YX, Chong MS, Lim WS, Tay L, Yew S, Yeo A, et al. Validity of estimating muscle and fat volume from a single MRI section in older adults with sarcopenia and sarcopenic obesity. Clinical Radiology. 2017;72(5):427.e9-.e14.
Yang YX, Chong MS, Tay L, Yew S, Yeo A, Tan CH. Automated assessment of thigh composition using machine learning for Dixon magnetic resonance images. Magnetic Resonance Materials in Physics, Biology and Medicine. 2016;29(5):723-31.
Tay L, Ding YY, Leung BP, Ismail NH, Yeo A, Yew S, …, Chong MS. Sex-specific differences in risk factors for sarcopenia amongst community-dwelling older adults. Age (Dordrecht, Netherlands). 2015;37(6):121.
Lim JP, Leung BP, Ding YY, Tay L, Ismail NH, Yeo A, …, Chong MS. Monocyte chemoattractant protein-1: a proinflammatory cytokine elevated in sarcopenic obesity. Clinical interventions in aging. 2015;10:605-9.
Chong MS, Tay L, Ismail NH, Tan CH, Yew S, Yeo A, …, Ding YY. The Case for Stage-Specific Frailty Interventions Spanning Community Aging to Cognitive Impairment. Journal of the American Medical Directors Association. 2015;16(11):1003.e13–.e19.


Osteosarcopenic Obesity in Non-Frail Older Adults: Influence of bone density definition on prevalence, body composition and muscle function.
Asian Conference for Frailty and Sarcopenia 2019. Taipei, Taiwan
(Oral category: Adjunct A/Prof Lim Wee Shiong)
Osteosarcopenic Obesity in Non-Frail Older Adults: Influence of bone density definition on prevalence, body composition and muscle function.
Asia Pacific International Association of Gerontology and Geriatrics 2019. Taipei, Taiwan
(Oral category: Adjunct A/Prof Lim Wee Shiong)
Muscle strength definitions matter in the EWGSOP2: influence on sarcopenia prevalence and predictive validity.
Asia Pacific International Association of Gerontology and Geriatrics 2019. Taipei, Taiwan
(Oral category: Adjunct A/Prof Lim Wee Shiong)
Social frailty association with health domains: findings from the GeriLABS 2 Study.
Asia Pacific International Association of Gerontology and Geriatrics 2019. Taipei, Taiwan
(Poster category: Miss Kalene Pek)
Exploring the diagnostic performance of the SARC-CalF-3 for sarcopenia screening amongst well community dwelling older adults.
American Geriatrics Society 2019. Portland, USA
(Poster category: Dr Chia Jia Qian)
Cardiometabolic profiles across body compositions: focus on sarcopenia and central adiposity.
European Geriatric Medicine Society 2019. Krakow, Poland
(Oral category: Dr Lim Jun Pei)
The association of Bioelectrical Impedance Analysis (BIA)- Derived phase angle with sarcopenia in non-frail community-dwelling older adults.
European Geriatric Medicine Society 2019. Krakow, Poland
(Oral category: Dr Justin Chew)
Applying the EWGSOP 2: Effect of muscle strength definitions on sarcopenia prevalence and predictive validity.
International Conference on Frailty and Sarcopenia Research 2019. Miami, USA
(Poster category: Adjunct A/Prof Lim Wee Shiong)
Screening for sarcopenia: evaluating the performance of different case-finding strategies using SARC-F in combination with muscle strength and performance measure.
International Conference on Frailty and Sarcopenia Research 2019. Miami, USA
(Poster category: Dr Justin Chew)
Sarcopenic Obesity in Asian populations: Influence of obesity definitions on prevalence and physical performance.
International Conference on Frailty and Sarcopenia Research 2019. Miami, USA
(Poster category: Mr Ezra Khor, Medical student)
Screening for sarcopenia: optimal cut-off points for calf circumference in community-dwelling older adults in Singapore.
Singapore Health and Biomedical Congress 2019. Singapore
(Poster category: Dr Loretta Wong)
Impact of EWGSOP2 crietria on classification of sarcopenia and clinical role of probable sarcopenia category.
Singapore Health and Biomedical Congress 2019. Singapore
(Poster category: Dr Herb Howard Hernandez)
Bioelectrical Impedance Analysis (BIA) phase angle – a new marker for diagnosing sarcopenia in older adults.
Singapore Health and Biomedical Congress 2019. Singapore
(Poster category: Dr Justin Chew)
Average versus maximum hand grip strength: Impact on sarcopenia prevalence and physical performance at 2 years.
Singapore Health and Biomedical Congress 2019. Singapore
(Poster category: Ms Suzanne Yew)
The EQ-5D-5L is more discriminative than the EQ-5D-3L in patients with osteosarcopenia in Singapore.
Singapore Health and Biomedical Congress 2019. Singapore
(Poster category: Ms Audrey Yeo)
Comparison of 5 Different measures of muscle strength amongst community dwelling older adults.
Singapore Health and Biomedical Congress 2019. Singapore
(Poster category: Ms Tan Cai Ning)
Association of MCP-1 and DKK-1 with body composition and physical performance parameters.
Singapore Health and Biomedical Congress 2019. Singapore
(Poster category: Ms Lock Hui Shin and Md Nathania Octaviani, Attachment students)
SARC-F and Anthropometric Measures: Enhancing Sarcopenia Screening in Clinical Practice.
International Conference on Frailty & Sarcopenia Research 2018. Miami Beach, USA
(Oral category: Adjunct A/Prof Lim Wee Shiong)
Defining a validated cutoff for pre-sarcopenia for risk assessment among community dwelling older persons
International Conference on Frailty & Sarcopenia Research 2018. Miami Beach, USA
(Poster category: Adjunct A/Prof Lim Wee Shiong)
Gender-specific Risk Factors for Sarcopenia Progression in Community-Dwelling Older Adults.
International Conference on Frailty & Sarcopenia Research 2018. Miami Beach, USA
(Poster category: Dr Laura Tay)
Sarcopenia, but not Frailty Predicts Falls in Well Older Adults with Diabetes
International Conference on Frailty & Sarcopenia Research 2018. Miami Beach, USA
(Poster category: Mr Delwyn Lim, Medical student)
Baseline Body Mass Index and Physical Activity Predicts 2-year Sarcopenia Progression in Community-Dwelling Older Adults: The GERI-LABS study.
International Conference of Frailty and Sarcopenia Research 2017, Barcelona, Spain
(Poster category: Adjunct A/Prof Lim Wee Shiong)
SARC-F: Defining a validated cutoff for pre-sarcopenia for risk assessment among community dwelling older persons.
Australian and New Zealand Society for Sarcopenia and Frailty Research 2017. Adelaide, Australia.
(Poster category: Adjunct A/Prof Lim Wee Shiong)
Construct and predictive validity of SARC-F as a risk assessment community screening tool for sacropenia
Australian and New Zealand Society for Sarcopenia and Frailty Research 2017. Adelaide, Australia.
(Poster category: Adjunct A/Prof Lim Wee Shiong)
Baseline Body Mass Index and Physical Activity Predicts 2-year Progression in Sarcopenia.
The Australian Association of Gerontology 2017. Perth, Australia
(Poster category: Adjunct A/Prof Lim Wee Shiong)
Combined impact of sarcopenia and frailty on physical function, cognition, and activity level in the community dwelling elderly.
3rd Asian Conference for Frailty and Sarcopenia 2017. Korea
(Poster category: Dr Raphael Lee)
Magnetic resonance imaging estimates of intermuscular fat density in the thigh in sarcopenia population: correlation with physical performances
International Society for Magnetic Resonance in Medicine 2017. Hawaii, USA
(Poster category: Dr Yang Yuxin)
Validity of estimating subcutaneous and visceral fat volume from single MRI slice in older adults with sarcopenia and sarcopenic obesity.
International Society for Magnetic Resonance in Medicine 2017. Hawaii, USA
(Poster category: Dr Yang Yuxin)
Longitudinal Changes in Nutritional Status; Sarcopenia Progression in Community-Dwelling Older Adult.
21st International Association of Gerontology and Geriatrics World Congress 2017. San Francisco, USA
(Poster category: Ms Suzanne Yew)
Trends and Predictors of 2-year Activity Participation in Community Dwelling Older Adults.
21st International Association of Gerontology and Geriatrics World Congress 2017. San Francisco, USA
(Poster category: Ms Audrey Yeo)
Physical Performance Beyond Muscle Mass in Cognitively Impaired Older Adults: Influence of Insulin-like Growth Factor-1 and Nutrition on Muscle Quality.
International Conference of Frailty and Sarcopenia Research 2016. Philadelphia, USA
(Poster category: Dr Laura Tay)
Preserved Functional Performance Despite Loss of Muscle Mass: Muscle Quality Matters.
Singapore Health and Biomedical Congress 2016. Singapore
(Poster category: Ms Nadine Foo, Medical student)
Quantification of Muscle and Fat Volumes in Dixon MRI of Thigh with Extreme Learning Machine.
10th International Association of Gerontology and Geriatrics (IAGG) Asia/Oceania Regional Congress 2015. Chiangmai, Thailand
(Oral category: Dr Yang Yuxin)
Dixon MRI with Extreme Learning Machine measures muscle and fat tissue volumes
RadiologyAsia 2015. Singapore
(Poster category: Dr Yang Yuxin)
Assessment of Adipose Tissue and Muscle Content Using Extreme Learning Machine for Dixon Magnetic Resonance Images of Thigh.
Singapore Health and Biomedical Congress 2015. Singapore
(Poster category: Dr Yang Yuxin)
Metabolic Syndrome (MetS) and its association with Sarcopenic Obesity (SO).
10th International Association of Gerontology and Geriatrics (IAGG) Asia/Oceania Regional Congress 2015. Chiangmai, Thailand
(Poster category: Ms Amanda Chong, Medical student)
Examining the Impact of Nutrition on Physical Performance and Sarcopenia in Functionally Independent Community-Dwelling Older Adults.
10th International Association of Gerontology and Geriatrics (IAGG) Asia/Oceania Regional Congress 2015. Chiangmai, Thailand
(Poster category: Ms Suzanne Yew)
Light Daily Physical Activity as a Potentially Modifiable Determinant of Sarcopenia in community dwelling older adults.
10th International Association of Gerontology and Geriatrics (IAGG) Asia/Oceania Regional Congress 2015. Chiangmai, Thailand
(Poster category: Ms Audrey Yeo)
Influence of Nutrition on Physical Performance and Sarcopenia in Functionally Independent community-dwelling older adults.
Singapore Health and Biomedical Congress 2015. Singapore
(Poster category: Ms Suzanne Yew)
Light Daily Physical Activity as a Potentially Modifiable Determinant of Sarcopenia in community dwelling older adults.
Singapore Health and Biomedical Congress 2015. Singapore
(Poster category: Ms Audrey Yeo)
Monocyte chemoattractant protein-1 (MCP-1): A pro-inflammatory cytokine elevated in sarcopenic obesity (SO).
67th Gerontological Society of America Annual Scientific Meeting 2014. Washington, DC
(Poster category: Dr Chong Mei Sian)
Sarcopenic obesity (SO): Consideration of fat mass beyond lean muscle in functional performance limitations in older adults.
Singapore Health and Biomedical Congress 2014. Singapore
(Oral category: Dr Chong Mei Sian)
Inflammation and the Interaction between Anabolic-Catabolic Pathways in Sarcopenia. 
Singapore Health and Biomedical Congress 2014. Singapore
(Oral category: Dr Laura Tay)


Best Poster Award – Allied Health (Bronze)
Miss Tan Cai Ning
Comparison of 5 different measures of muscle strength amongst community-dwelling older adults: insights from GeriLABS 2 study.
Singapore Health & Biomedical Congress 2019. Singapore.
Best Poster Award – Allied Health (Gold)
Miss Audrey Yeo 
Combined impact of Sarcopenia and frailty on health-related Quality of Life. Results from the GeriLABS study
Singapore Health & Biomedical Congress 2018. Singapore.
Outstanding Abstract Oral Presentation
Adjunct A/Prof Lim Wee Shiong
Construct and predictive validity of SARC-F as a risk assessment community screening tool for sarcopenia.
Australian and New Zealand Society for Sarcopenia and Frailty Research 2017. Adelaide, Australia.
Young Investigator Award
Dr Yang Yuxin
MRI estimation of Intermuscular Fat Density in Thigh in a Sarcopenia Population correlation with physical Performance.
Radiology Asia 2017. Singapore.
Best Poster Award (Bronze)
Ms Suzanne Yew
Examining the Impact of Nutrition on Physical Performance and Sarcopenia in Functionally Independent Community-Dwelling Older Adults.
Asia Pacific Geriatrics Conference 2016. Singapore.
Young Investigator Award – Clinical Research (Gold)
Dr Laura Tay
Inflammation and the Interaction between Anabolic-Catabolic Pathways in Sarcopenia.
Singapore Health & Biomedical Congress 2014. Singapore.


04 OCTOBER 2019

First-of-its-kind study sheds new light on sarcopenic obesity

Sarcopenic obesity or "fat frailty" is a little-known health condition that could have a big impact on older persons. Emerging in recent years as a global phenomenon, sarcopenic obesity confluences our rapidly ageing population and rising obesity rate, and is associated with poorer health outcomes.

22 SEPTEMBER 2019

Tackling ageing issues: Turning silver into gold as Singaporeans live longer

With life expectancy of Singaporeans rising steadily, living to 100 years might no longer be a pipe dream down the road. The Straits Times ‘Healthy For 100’ Roundtable, featured four key stakeholders in the field of ageing, including IGA’s Deputy Director A/Prof Lim Wee Shiong, to discuss pressing issues that Singaporeans will have to tackle as they enter their golden years.

















2020/10/21