Research Publications

Notwithstanding competing challenges from their clinical, educator and administrator roles, our clinicians have been heavily involved in a wide range of research and publishing steadily over the past years. Multi- and interdisciplinary collaborations with both local and international researchers have propelled IGA further in our growth.

​Afandy NO, Lock HS, Tay L, Yeo A, Yew S, Leung BP, Lim WS. Association of Monocyte Chemotactic Protein-1 and Dickkopf-1 with Body Composition and Physical Performance in Community-Dwelling Older Adults in Singapore. J Frailty Sarcopenia Falls. 2021;6(1):25-31. doi:10.22540/jfsf-06-025
Ali N, Anthony P, Lim WS, Chong MS, Poon EWH, Drury V, Chan M. Exploring Differential Perceptions and Barriers to Advance Care Planning in Dementia among Asian Patient–Caregiver Dyads—A Mixed-Methods Study. International journal of environmental research and public health. 2021;18(13):7150. doi: 660-4601/18/13/7150
​Chong E, Chan M, Tan HN, Lim WS. Heterogeneity in functional status among moderately frail older adults: improving predictive performance using a modified approach of subgrouping the Clinical Frailty Scale. European Geriatric Medicine. 2021;12(2):275-84. doi:10.1007/s41999-020-00418-8
Chong E, Huang Y, Chan M, Tan HN, Lim WS. Concurrent and Predictive Validity of FRAIL-NH in Hospitalized Older Persons: An Exploratory Study. J Am Med Dir Assoc. 2021; 2021/05/19. doi: 10.1016/j.jamda.2021.04.017. [Epub ahead of print].
​Chong E, Tham A, Chew J, Lim WS, Tan HN, Ang H, Chan M. Brief Aids to Guide Clinical Frailty Scale Scoring at the Front Door of Acute Hospitals. Journal of the American Medical Directors Association. 2021;22(5):1116-7.e2. doi:10.1016/j.jamda.2021.02.005
​Chong E, Zhu B, Tan H, Molina JC, Goh EF, Baldevarona-Llego J, Chia JQ, Chong A, …, Chan M, Lim WS. Emergency Department Interventions for Frailty (EDIFY): Front-Door Geriatric Care Can Reduce Acute Admissions. J Am Med Dir Assoc. 2021;22(4):923-8.e5. doi: http://10.1016/j.jamda.2021.01.083
​Chua KY, Lin X, Wang Y, Chong YS, Lim WS, Koh WP. Visceral fat area is the measure of obesity best associated with mobility disability in community dwelling oldest-old Chinese adults. BMC Geriatrics. 2021;21(1):282. doi:10.1186/s12877-021-02226-6
​George PP, Lun P, Ong SP, Lim WS. A Rapid Review of the Measurement of Intrinsic Capacity in Older Adults. The journal of nutrition, health & aging. 2021;25(6):774-82. doi:10.1007/s12603-021-1622-6
​Ho EP, Neo H-Y. COVID 19: prioritise autonomy, beneficence and conversations before score-based triage. Age and ageing. 2021;50(1):11-5. doi:10.1093/ageing/afaa205
​Kua J, Lim WS, Teo W, Edwards RA. A scoping review of adaptive expertise in education. Med Teach. 2021;43(3):347-55. doi:10.1080/0142159x.2020.1851020
​Lee CF, Seow D, Teo I, Neo S, Yang GM, Lee GL, Lim WS, et al. Development of a short form of the Singapore Caregiver Quality of Life Scale - Dementia: SCQOLS-D-15. Journal of patient-reported outcomes. 2021;5(1):56. doi:10.1186/s41687-021-00330-0
Liaw SY, Choo T, Wu LT, Lim WS, Choo H, Lim SM, et al. "Wow, woo, win": Healthcare students' and facilitators' experiences of interprofessional simulation in three-dimensional virtual world: A qualitative evaluation study. Nurse Education Today. 2021;105:105018. doi:10.1016/j.nedt.2021.105018
​Lim JP, Chew J, Ismail N, Lim WS. Obesity Definition for Muscle Outcomes in Sarcopenic Obesity: Utility of Waist Circumference Revisited. The Journal of Frailty & Aging. 2021. doi: 10.14283/jfa.2021.28. [Epub ahead of print].
Lim JP, Low K, Lin N, Lim C, Ong S, Tan W, …, Tan HN, …, Lim WS. Predictors for development of critical illness amongst older adults with COVID-19: Beyond age to age-associated factors. Archives of Gerontology and Geriatrics. 2021;94:104331. doi:10.1016/j.archger.2020.104331
​Lim WS. Sarcopenia: Update on Diagnosis and Treatment in an Asian Community Setting. Singapore Family Physician. 2021;47(6):5-12.
​Lu Y, Gwee X, Chua DQ, Lee TS, Lim WS, Chong MS, et al. Nutritional Status and Risks of Cognitive Decline and Incident Neurocognitive Disorders: Singapore Longitudinal Ageing Studies. J Nutr Health Aging. 2021;25(5):660-7. doi:10.1007/s12603-021-1603-9
​Ng TP, Lee TS, Lim WS, Chong MS, Yap P, Cheong CY, et al. Development, Validation and Field Evaluation of the Singapore Longitudinal Ageing Study (SLAS) Risk Index for Prediction of Mild Cognitive Impairment and Dementia. J Prev Alzheimers Dis. 2021;8(3):335-44. doi:10.14283/jpad.2021.19
Pek K, Tan CN, Yew S, Yeo A, Lim JP, Chew J, Lim WS. COVID-19 Pandemic Control Measures: Impact on Social Frailty and Health Outcomes in Non-Frail Community-Dwelling Older Adults. The journal of nutrition, health & aging. 2021. doi: 10.1007/s12603-021-1635-1. [Epub ahead of print]. doi:10.1007/s12603-021-1635-1
Tan H, How AX, Wang XX, Lee JE, Lim WS. COVID-19 and Persons with Dementia in Acute Care Settings: How to "Evade" Challenging Behaviors. The Journal of Frailty & Aging. 2021;10(1):73-4. doi:10.14283/jfa.2020.53

Ali N, Tan CN, Kang J, Chew AP, Caroline C, Lee M, Lim WS. Bridging Biomedical and Person-centered Care Approaches via Namaste Care with Family Participation: An Asian Experience in Advanced Dementia Treatment. OBM Geriatrics. 2020;4(4). doi:10.21926/obm.geriatr.2004140
Chen LK, Woo J, Assantachai P, Auyeung TW, Chou MY, Iijima K, …, Lim WS, et al. Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment. Journal of the American Medical Directors Association. 2020;21(3):300-7.e2. doi:10.1016/j.jamda.2019.12.012
Cheung YB, Teo I, Lim WS, Hum A, Neo S, Yang G, et al. Development and evaluation of the Singapore Caregiver Quality of Life Scale - Dementia. Journal of patient-reported outcomes. 2020;4(1):84-. doi:10.1186/s41687-020-00252-3
Chew J, Yeo A, Yew S, Lim JP, Tay L, Ding YY, Lim WS. Muscle Strength Definitions Matter: Prevalence of Sarcopenia and Predictive Validity for Adverse Outcomes Using the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) Criteria. The Journal of Nutrition, Health and Aging. 2020;24(6):614-8. doi:10.1007/s12603-020-1371-y
Chew J, Yeo A, Yew S, Tan CN, Lim JP, Hafizah Ismail N, Lim WS. Nutrition Mediates the Relationship between Osteosarcopenia and Frailty: A Pathway Analysis. Nutrients. 2020;12(10). doi:10.3390/nu12102957
Chong E, Chan M, Tan HN, Lim WS. Heterogeneity in functional status among moderately frail older adults: improving predictive performance using a modified approach of subgrouping the Clinical Frailty Scale. European Geriatric Medicine. 2020; Oct 23: 1-10. 
​Chong E, Chan M, Tan HN, Lim WS. COVID-19: Use of the Clinical Frailty Scale for Critical Care Decisions. Journal of the American Geriatrics Society. 2020;68(6):E30-e2. doi:10.1111/jgs.16528
Chow A, Htun HL, Kyaw WM, Ang H, Tan G, Tan HN, et al. Atypical COVID-19: Preventing transmission from unexpected cases. Infect Control Hosp Epidemiol. 2020; 2020/08/14. doi: 10.1017/ice.2020.419. [Epub ahead of print]
Chua KY, Lim WS, Lin X, Yuan JM, Koh WP. Handgrip Strength and Timed Up-and-Go (TUG) Test are Predictors of Short-Term Mortality among Elderly in a Population-Based Cohort in Singapore. The Journal of Nutrition, Health and Aging. 2020;24(4):371-8. doi:10.1007/s12603-020-1337-0
Goh EF, Tan CN, Pek K, Leong S, Wong WC, Lim WS. Not Wasting a Crisis: How Geriatrics Clinical Research Can Remain Engaged During COVID-19. Journal of the American Geriatrics Society. 2020;68(8):1676-7. doi:10.1111/jgs.16569
Guerini FR, Lim WS, Arosio B. Editorial: Biomarkers to Disentangle the Physiological From Pathological Brain Aging. Frontiers in Aging Neuroscience. 2020;12:88. doi:10.3389/fnagi.2020.00088
Hum A, Tay RY, Wong YKY, Ali NB, Leong IYO, Wu HY, …, Koh MYH. Advanced dementia: an integrated homecare programme. BMJ Support Palliat Care. 2020;10(4):e40. doi: 10.1136/bmjspcare-2019-001798.
​Kaur P, Tan WS, Gunapal PPG, Ding YY, Ong R, Wu HY, et al. Deaths in dementia: a scoping review of prognostic variables. BMJ Supportive & Palliative Care. 2020. doi: 10.1136/bmjspcare-2020-002217. [Epub ahead of print]
Khor E, Lim JP, Tay L, Yeo A, Yew S, Ding YY, Lim WS. Obesity Definitions in Sarcopenic Obesity: Differences in Prevalence, Agreement and Association with Muscle Function. The Journal of frailty & aging. 2020;9(1):37-43. doi:10.14283/jfa.2019.28
Koh ZY, Law F, Chew J, Noor A, Lim WS. Impact of Coronavirus Disease Pandemic on Persons with Dementia and Their Caregivers: An Audit Study. Annals of Geriatric Medicine and Research. 2020; Oct 10.
​Kua J, Lim WS, Teo W, Edwards RA. A scoping review of adaptive expertise in education. Medical Teacher. 2020;43(3):347-55. doi:10.1080/0142159X.2020.1851020
​Lau S, Lun P, Ang W, Tan KT, Ding YY. Barriers to effective prescribing in older adults: applying the theoretical domains framework in the ambulatory setting – a scoping review. BMC Geriatrics. 2020;20(1):459. doi:10.1186/s12877-020-01766-7
Lau S, Pek K, Chew J, Lim JP, Hafizah N, Ding YY, …, Lim WS. The Simplified Nutritional Appetite Questionnaire (SNAQ) as a Screening Tool for Risk of Malnutrition: Optimal Cutoff, Factor Structure, and Validation in Healthy Community-Dwelling Older Adults. Nutrients. 2020;12(9). doi:10.3390/nu12092885
​Lee ES, Lee PSS, Chew EAL, Muthulingam G, Koh HL, Tan SY, Ding YY. Video Consultations for Older Adults With Multimorbidity During the COVID-19 Pandemic: Protocol for an Exploratory Qualitative Study. JMIR research protocols. 2020;9(10):e22679-e. doi:10.2196/22679
Lee JQ, Ying K, Lun P, Tan KT, Ang W, Munro Y, Ding YY. Intervention elements to reduce inappropriate prescribing for older adults with multimorbidity receiving outpatient care: a scoping review. BMJ Open. 2020;10(8):e039543. doi:10.1136/bmjopen-2020-039543
​Lee R, Ho E, Neo HY, Hum A, Lim WS. Letter to the Editor: Setting Goals or Shifting Goalposts: Role of Frailty for Critical Care Decisions during COVID-19. The Journal of Frailty & Aging. 2020;9(4):246-7. doi:10.14283/jfa.2020.46
​Lee SY, Kua A, Qiu W, Lai KY, Jumala J, Yong  L, …, Lim WS. Exercise as Medicine in Frailty Prevention and Management: Why Now, Why Here, and Making it Happen. ANNALS Academy of Medicine Singapore. 2020;49:810-3. doi:10.47102/annals-acadmedsg.2020158
Liaw SY, Wu LT, Soh SLH, Ringsted C, Lau TC, Lim WS. Virtual Reality Simulation in Interprofessional Round Training for Health Care Students: A Qualitative Evaluation Study. Clinical Simulation in Nursing. 2020;45:42-6. doi:
Lim JP, Yew S, Tay L, Chew J, Yeo A, Hafizah N, Ding YY, Lim WS. Grip Strength Criterion Matters: Impact of Average Versus Maximum Handgrip Strength on Sarcopenia Prevalence and Predictive Validity for Low Physical Performance. The journal of nutrition, health & aging. 2020;24(9):1031-1035. doi: 10.1007/s12603-020-1461-x.
Lim WS, Liang CK, Assantachai P, Auyeung TW, Kang L, Lee WJ, et al. COVID-19 and older people in Asia: Asian Working Group for Sarcopenia calls to actions. Geriatrics & gerontology international. 2020;20(6):547-58. doi:10.1111/ggi.13939
Lim WS, Lim JP, Chew J, Tan A. Calf Circumference as a Case-Finding Tool for Sarcopenia: Influence of Obesity on Diagnostic Performance. J Am Med Dir Assoc. 2020;21(9):1359-61. doi:10.1016/j.jamda.2020.03.033
​Lim WS, Lim J, Chew J, Tan A. Influence of Obesity on Diagnostic Accuracy and Optimal Cutoffs for Sarcopenia Screening in Non-Frail Older Adults: A Comparison of SARC-F Versus SARC-CalF. The journal of nutrition, health & aging. 2020;24(8):914-6. doi:10.1007/s12603-020-1393-5
Neo HY, Tan KT, Caroline C, Ng D, Ho E, Lim JP, Lee R, …, Ding YY. Higher rates of carbapenem-related seizures in older hospitalised adults. The Journal of Internal Medicine. 2020;50(1):123-7. doi:10.1111/imj.14693
Ong YH, Koh M, Lim WS. Shared leadership in interprofessional teams: beyond team characteristics to team conditions. Journal of Interprofessional Care. 2020;34(4):444-52. doi:10.1080/13561820.2019.1653834
Pang J, Tan HN, Mak TM, Octavia S, Maurer-Stroh S, Sirota F, et al. A COVID-19 Nursing Home Cluster Linked to a Household Transmission: An Epidemiological, Clinical and Phylogenetic Investigation. SSRN; 2020.
Pek K, Chew J, Lim JP, Yew S, Tan CN, Yeo A, Ding YY, Lim WS. Social Frailty Is Independently Associated with Mood, Nutrition, Physical Performance, and Physical Activity: Insights from a Theory-Guided Approach. International journal of environmental research and public health. 2020;17(12):4239. doi:10.3390/ijerph17124239
Pereira MJ, Tay RY, Tan WS, Molina JAC, Ali NB, Leong IYO, Wu HY, Chin JJ, …, Koh MYH, Hum AYM. Integrated palliative homecare in advanced dementia: reduced healthcare utilisation and costs. BMJ Supportive & Palliative Care. 2020; May 20. doi: 10.1136/bmjspcare-2019-002145. [Epub ahead of print].
Tay RY, Hum A, Ali N, Leong I, Wu HY, Chin JJ, et al. Comfort and Satisfaction With Care of Home-Dwelling Dementia Patients at the End of Life. J Pain Symptom Manage. 2020;59(5):1019-32.e1. doi:10.1016/j.jpainsymman.2019.12.004
​Wang X, Lu Y, Li C, Larbi A, Feng L, Shen Q, …, Lim WS, et al. Associations of lifestyle activities and a heathy diet with frailty in old age: a community-based study in Singapore. Aging. 2020;12(1):288-308. doi:10.18632/aging.102615

Cabradilla J, Ong PL, Villaverde E, Marasigan E, Declarador N, Tan KT, Tan HN, Ding YY. The Safety of Treatment with Cefepime in Elderly Patients. Aging Medicine and Healthcare. 2019;10:139-45. doi:10.33879/AMH.2019.125-1805.010
Chan EY, Lim ZX, Ding YY, Chan YH, Lim WS. Development of a Brief Caregiver-centric Screening Tool to Identify Risk of Depression among Caregivers of Hospitalized Older Adults. Journal of Nutrition, Health and Aging. 2019;23(6):578-85. doi:10.1007/s12603-019-1197-7
Chan EY, Phang KN, Glass GFJ, Lim WS. Crossing, Trudging and Settling: A phenomenological inquiry into lived experience of Asian family caregivers of older persons with dementia. Geriatrics Nursing. 2019;40(5):502-9. doi:10.1016/j.gerinurse.2019.03.015
Cheong TS, Goh WY, Ong EH, Abdul-Karim SN, See LL, Chong E. The Prevalence of Frailty and Its Association with Adverse Drug Reactions in Hospitalized Older Adults. Journal of Geriatric Medicine and Gerontology. 2019;5(3):8. doi:10.23937/2469-5858/1510076
Chew BH, Tang CJ, Lim WS, Yap J, Zhou W, Liaw SY. Interprofessional bedside rounds: Nurse-physician collaboration and perceived barriers in an Asian hospital. Journal of interprofessional care. 2019;33(6):820-2.  doi:10.1080/13561820.2019.1566218
Chew J, Tay L, Lim JP, Leung BP, Yeo A, Yew S, Ding YY, Lim WS. Serum Myostatin and IGF-1 as Gender-Specific Biomarkers of Frailty and Low Muscle Mass in Community-Dwelling Older Adults. The Journal of Nutrition, Health and Ageing. 2019;23(10):979-86. doi:10.1007/s12603-019-1255-1
Chong E, Chia JQ, Law F, Chew J, Chan M, Lim WS. Validating a Standardised Approach in Administration of the Clinical Frailty Scale in Hospitalised Older Adults. Annals of the Academy of Medicine, Singapore. 2019;48(4):115-24.
Heyzer L, Ali N, Chew AP, Chan M, Lim WS. Worry about Performance: Unravelling the Relationship between 'Doing More' and 'Doing Better'. The Journal of Nutrition, Health and Aging. 2019;23(9):843-8. doi:10.1007/s12603-019-1225-7
Hum A, Tay RY, Wong YKY, Ali NB, Leong IYO, Wu HY, Chin JJ, Lee AOK, Koh MYH. Advanced dementia: an integrated homecare programme. BMJ Support Palliat Care. 2019; June 25. doi: 10.1136/bmjspcare-2019-001798
Lau S, Ali N, Lim JP, Lim WS. ZBI multidimensionality: The salience of worry about performance. International psychogeriatrics. 2019;31(6):909-11. doi:10.1017/S1041610218001217
Lim JP, Chong MS, Tay L, Yang YX, Leung BP, Yeo A, …, Lim WS. Inter-muscular adipose tissue is associated with adipose tissue inflammation and poorer functional performance in central adiposity. Archives of Gerontology and Geriatrics. 2019;81:1-7. doi:10.1016/j.archger.2018.11.006
Lim WS, Chew J, Lim JP, Tay L, Ismail NH, Ding YY. Case for Validated Instead of Standard Cut-Offs for SARC-CalF. The Journal of Nutrition, Health and Aging. 2019;23(4):393-5. doi: 10.1007/s12603-019-1177-y
Lim WS, Tham KM, Adzahar FB, Neo HY, Wong WC, Lim I, et al. Trends of clarification purpose of medical education research in the Asia-Pacific region: A scoping review. The Asia Pacific Scholar. 2019;4(1):24-33. doi:10.29060/TAPS.2019-4-1/OA1063
Lim WS, Wong CH, Ding YY, Rockwood K, Lien C. Translating the Science of Frailty in Singapore: Results from the National Frailty Consensus Discussion. Annals of the Academy of Medicine, Singapore. 2019;48(1):25-31.
Malhotra R, Bautista MAC, Muller AM, Aw S, Koh G, Theng YL…, Lim WS, et al. The Aging of a Young Nation: Population Aging in Singapore. Gerontologist. 2019;59(3):401-10. doi:10.1093/geront/gny160

Chan EY, Glass G, Chua KC, Ali N, Lim WS. Relationship between Mastery and Caregiving Competence in Protecting against Burden, Anxiety and Depression among Caregivers of Frail Older Adults. The Journal of Nutrition, Health and Aging. 2018;22(10):1238-45. doi:10.1007/s12603-018-1098-1
Chong E, Chan M, Lim WS, Ding YY. Frailty Predicts Incident Urinary Incontinence Among Hospitalized Older Adults-A 1-Year Prospective Cohort Study. Journal of the American Medical Directors Association. 2018;19(5):422-7. doi:10.1016/j.jamda.2017.12.103
Chong E, Chan M, Lim WS, Ding YY. Response to the Letter to the Editor: Flaws Related to the Article Entitled "Frailty Predicts Incident Urinary Incontinence Among Hospitalized Older Adults". Journal of the American Medical Directors Association. 2018;19(11):1020-1. doi:10.1016/j.jamda.2018.07.002
Chong E, Ho E, Baldevarona-Llego J, Chan M, Wu L, Tay L, Ding YY, Lim WS. Frailty in Hospitalized Older Adults: Comparing Different Frailty Measures in Predicting Short- and Long-term Patient Outcomes. Journal of the American Medical Directors Association. 2018;19(5):450-7.e3. doi:10.1016/j.jamda.2017.10.006
Chong MS, Tan CN, Yew S, Lim JP, Lim WS, Lieu PK. Successful Ageing in Nonagenarians: Bio-psychosocial Factors Determining Successful Ageing in Long-Lived Older Adults. Journal of the American Medical Directors Association. 2018;19(1):90-2. doi:10.1016/j.jamda.2017.10.015
Declarador N, Ramason R, Tay L, Chan W, Kwek E. Beyond comanaged inpatient care to community integration: Factors leading to surgical delay in hip fractures and their associated outcomes. Journal of orthopaedic surgery (Hong Kong). 2018;26(2):2309499018783909. doi:10.1177/2309499018783909
Gao Q, Gwee X, Feng L, Nyunt MS, Collinson SL, Chong MS, Lim WS, et al. Mild Cognitive Impairment Reversion and Progression: Rates and Predictors in Community-Living Older Persons in the Singapore Longitudinal Ageing Studies Cohort. Dementia and Geriatric Cognitive Disorders Extra 2018;8(2):226-37. doi:10.1159/000488936
Kua J, Chan M, See J, Ng D, Lim WS. STarDom study - Applying systems theory framework for Internal Medicine senior residency career development in a Singapore ACGMEI Residency Programme. The Asia-Pacific Scholar. 2018;3(2):6-18. doi:10.29060/TAPS.2018-3-2/OA1046
Kumar R, Teo EK, How CH, Wong TY, Ang TL. A practical clinical approach to liver fibrosis. Singapore medical journal. 2018;59(12):628-33. doi:10.11622/smedj.2018145
Li J, Cesari M, Del Campo N, Andrieu S, Dong B, Lim WS, et al. Impact of diabetes on caregiver stress in patients with Alzheimer's disease: data from the ICTUS study. International psychogeriatrics. 2018;30(8):1109-17. doi:10.1017/s1041610217002460
Li R, Chong MS, Chan M, Tay L, Ali N, Lim WS. Worry About Caregiving Performance: A Confirmatory Factor Analysis. Frontiers in Medicine. 2018;5:79. doi:10.3389/fmed.2018.00079
Liaw SY, Carpio GAC, Lau Y, Tan SC, Lim WS, Goh PS. Multiuser virtual worlds in healthcare education: A systematic review. Nurse education today. 2018;65:136-49. doi:10.1016/j.nedt.2018.01.006
Lim JP, Chong MS, Tay L, Yang YX, Leung BP, Yeo A, …, Lim WS. Inter-muscular adipose tissue is associated with adipose tissue inflammation and poorer functional performance in central adiposity. Archives of Gerontology and Geriatrics. 2018;81:1-7. doi:10.1016/j.archger.2018.11.006
Lim WS, Canevelli M, Cesari M. Editorial: Dementia, Frailty and Aging. Frontiers in Medicine. 2018;5:168. doi:10.3389/fmed.2018.00168
Lim WS, Tay L, Yeo A, Yew S, Hafizah N, Ding YY. Modulating Effect of Contextual Factors on Factor Structure and Reliability of SARC-F. Journal of the American Medical Directors Association. 2018;19(6):551-3. doi:10.1016/j.jamda.2018.02.009
Loo ME, Krishnasamy C, Lim WS. Considering Face, Rights, and Goals: A Critical Review of Rapport Management in Facilitator-Guided Simulation Debriefing Approaches. Simulation in healthcare : journal of the Society for Simulation in Healthcare. 2018;13(1):52-60. doi:10.1097/sih.0000000000000258
Tay L, Leung BP, Wee S, Tay KS, Ali N, Chan M, Lim WS. Association of nutrition and immune-endocrine dysfunction with muscle mass and performance in cognitively impaired older adults. Archives of Gerontology and Geriatrics. 2018;75:20-7. doi:10.1016/j.archger.2017.11.008
Wong J, Archarya R, Kwang HM, Kam YT, Tan E, Ting J, Lim WS. SimRound, A novel approach to transitions of Junior Medical Students into Clinical Clerkships: Rationale, Development and Lessons Learnt. MedEdPublish. 2018;7:40. doi:10.15694/mep.2018.0000178.1

Abengana J, Chong MS, Tay L. Delirium superimposed on dementia: phenomenological differences between patients with and without behavioral and psychological symptoms of dementia in a specialized delirium unit. International Psychogeriatrics. 2017;29(3):485-95. doi:10.1017/s1041610216001836
Ch'ng A, Yong K, Ng D, Heyzer L, Lim WS. Trends in Geriatrics-Related Translational Research and Funding in the "Big 4" Medical Journals. Journal of the American Medical Directors Association. 2017;18(6):544-5. doi:1016/j.jamda.2017.02.018
Chew J, Lim WS, Chong MS, Ding YY, Tay L. Impact of frailty and residual subsyndromal delirium on 1-year functional recovery: A prospective cohort study. Geriatrics and Gerontology International. 2017;17(12):2472-8. doi:10.1111/ggi.13108
Chong E, Ho E, Baldevarona-Llego J, Chan M, Wu L, Tay L. Frailty and Risk of Adverse Outcomes in Hospitalized Older Adults: A Comparison of Different Frailty Measures. Journal of the American Medical Directors Association. 2017;18(7):638.e7-.e11. doi:10.1016/j.jamda.2017.04.011
Dent E, Lien C, Lim WS, Wong WC, Wong CH, Ng TP, et al. The Asia-Pacific Clinical Practice Guidelines for the Management of Frailty. Journal of the American Medical Directors Association. 2017;18(7):564-75. doi:10.1016/j.jamda.2017.04.018
Ding YY. Predictive Validity of Two Physical Frailty Phenotype Specifications Developed for Investigation of Frailty Pathways in Older People. Gerontology. 2017;63(5):401-10. doi:10.1159/000471803
Ding YY, Kuha J, Murphy M. Multidimensional predictors of physical frailty in older people: identifying how and for whom they exert their effects. Biogerontology. 2017;18(2):237-52. doi:10.1007/s10522-017-9677-9
Ding YY, Kuha J, Murphy M. Pathways from physical frailty to activity limitation in older people: Identifying moderators and mediators in the English Longitudinal Study of Ageing. Experimental Gerontology. 2017;98:169-76. doi:10.1016/j.exger.2017.08.029
Feng L, Lim WS, Chong MS, Lee TS, Gao Q, Nyunt MS, et al. Depressive Symptoms Increase the Risk of Mild Neurocognitive Disorders among Elderly Chinese. The Journal of Nutrition, Health and Aging. 2017;21(2):161-4. doi:10.1007/s12603-016-0765-3
Feng L, Nyunt MS, Gao Q, Lee TS, Tsoi T, Chong MS, Lim WS, et al. Physical Frailty, Cognitive Impairment, and the Risk of Neurocognitive Disorder in the Singapore Longitudinal Ageing Studies. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2017;72(3):369-75. doi:10.1093/gerona/glw050
Heywood R, Gao Q, Nyunt MS, Feng L, Chong MS, Lim WS, et al. Hearing Loss and Risk of Mild Cognitive Impairment and Dementia: Findings from the Singapore Longitudinal Ageing Study. Dementia and Geriatric Cognitive Disorders. 2017;43(5-6):259-68. doi:10.1159/000464281
Koh ZY, Lim S, Lim WS. An Interesting Case of "Refractory" Hypomagnesemia. Journal of the American Medical Directors Association. 2017;18(7):632-3. doi:10.1016/j.jamda.2017.04.009
Lim WS, Tham KM, Adzahar FB, Neo HY, Wong WC, Ringsted C. Determinants of clarification research purpose in medical education research: A systematic review. The Aisa-Pacific Scholar. 2017;2(2):8-17. doi: 10.29060/TAPS.2017-2-2/OA1004
Lim WS, Wong SF, Leong I, Choo P, Pang WS. Forging a Frailty-Ready Healthcare System to Meet Population Ageing. International Journal Environmental Research and Public Health. 2017;14(12):E1448. doi:10.3390/ijerph14121448
Nyunt MS, Soh CY, Gao Q, Gwee X, Ling A, Lim WS, et al. Characterisation of Physical Frailty and Associated Physical and Functional Impairments in Mild Cognitive Impairment. Frontiers in Medicine. 2017;4(18):230.doi:10.3389/fmed.2017.00230
Ong SY, Tan N, Knab MS, Farrell SE, Lim WS. Attitudes of clinician educators towards interprofessional education and collaboration: Insights from two interprofessional scales. Journal of interprofessional care. 2017;31(5):656-60. doi:10.1080/13561820.2017.1320275
Rawtaer I, Gao Q, Nyunt MS, Feng L, Chong MS, Lim WS, et al. Psychosocial Risk and Protective Factors and Incident Mild Cognitive Impairment and Dementia in Community Dwelling Elderly: Findings from the Singapore Longitudinal Ageing Study. American Journal of Alzheimers Disease and Other Dementias. 2017;57(2):603-11. doi:10.3233/jad-160862
Teo WL, Lee M, Lim WS. The relational activation of resilience model: How leadership activates resilience in an organizational crisis. Journal of Contingencies and Crisis Management. 2017;25:136-47. doi:10.1111/1468-5973.12179
Walsh K, Noben C, Gregory S, Lim WS, Green C, Roberts T, et al. Cost benefit analysis of healthcare professional education: report of a conference workshop. BMJ Simulation and Technology Enhanced Learning. 2017;4(2):95-6. doi:10.1136/bmjstel-2017-000214
Win KK, Chong MS, Ali N, Chan M, Lim WS. Burden among Family Caregivers of Dementia in the Oldest-Old: An Exploratory Study. Frontiers in Medicine. 2017;4:205. doi:10.3389/fmed.2017.00205
Yang YX, Chong MS, Lim WS, Tay L, Yew S, Yeo A, et al. Validity of estimating muscle and fat volume from a single MRI section in older adults with sarcopenia and sarcopenic obesity. Clinical Radiology. 2017;72(5):427.e9-.e14. doi:10.1016/j.crad.2016.12.011
Yock Y, Lim I, Lim YH, Lim WS, Chew N, Archuleta S. Sometimes Means Some of the Time: Residents' Overlapping Responses to Vague Quantifiers on the ACGME-I Resident Survey. Journal of Graduate Medical Education. 2017;9(6):735-40. doi:10.4300/jgme-d-17-00187.1
Zhao YJ, Lim WS. Dabigatran Compared With Rivaroxaban vs Warfarin. JAMA Internal Medicine. 2017;177(5):742. doi:10.1001/jamainternmed.2017.0564

Chan CY, Sum MY, Lim WS, Chew NW, Samarasekera DD, Sim K. Adoption and correlates of Postgraduate Hospital Educational Environment Measure (PHEEM) in the evaluation of learning environments - A systematic review. Medical Teacher. 2016;38(12):1248-55.
Chew J, Cheong S, Tay L. Quetiapine-Induced Cutaneous Vasculitis: Diagnostic Challenges and Therapeutic Implications. Journal of American Geriatrics Society. 2016;64(5):1137-8.
Ding YY. Developing physical frailty specifications for investigation of frailty pathways in older people. Age (Dordrecht, Netherlands). 2016;38(2):47.
Feng L, Chong MS, Lim WS, Gao Q, Nyunt MS, Lee TS, et al. Tea Consumption Reduces the Incidence of Neurocognitive Disorders: Findings from the Singapore Longitudinal Aging Study. The Journal of Nutrition, Health and Aging. 2016;20(10):1002-9.
Kua J, Ramason R, Rajamoney G, Chong MS. Which frailty measure is a good predictor of early post-operative complications in elderly hip fracture patients? Archives of orthopaedic and trauma surgery. 2016;136(5):639-47.
Lee SY, Dong L, Lim YH, Poh CL, Lim WS. SBAR: towards a common interprofessional team-based communication tool. Medical education. 2016;50(11):1167-8.
Loke SC, Lim WS, Someya Y, Hamid TA, Nudin SSH. Examining the Disability Model From the International Classification of Functioning, Disability, and Health Using a Large Data Set of Community-Dwelling Malaysian Older Adults. Journal of Aging and Health. 2016;28(4):704-25.
Ng TP, Feng L, Nyunt MS, Feng L, Gao Q, Lim ML, …, Chong MS, Lim WS, et al. Metabolic Syndrome and the Risk of Mild Cognitive Impairment and Progression to Dementia: Follow-up of the Singapore Longitudinal Ageing Study Cohort. JAMA Neurology. 2016;73(4):456-63.
Ong YH, Lim I, Tan KT, Chan M, Lim WS. Assessing shared leadership in interprofessional team meetings: A validation study. The Asia Pacific Scholar. 2016;1(1):9-19.
Rawtaer I, Feng L, Yuen VH, Li J, Chong MS, Lim WS, et al. A Risk Score for the Prediction of Neurocognitive Disorders among Community-Dwelling Chinese Older Adults. Dementia and geriatric cognitive disorders. 2016;41(5-6):348-58.
Tay L, Lim WS, Chan M, Ali N, Chong MS. A Combined Cognitive Stimulation and Physical Exercise Programme (MINDVital) in Early Dementia: Differential Effects on Single- and Dual-Task Gait Performance. Gerontology. 2016;62(6):604-10.
Tay L, Lim WS, Chan M, Ye RJ, Chong MS. The Independent Role of Inflammation in Physical Frailty among Older Adults with Mild Cognitive Impairment and Mild-to-Moderate Alzheimer's Disease. The Journal of Nutrition, Health and Aging. 2016;20(3):288-99.
Yang YX, Chong MS, Tay L, Yew S, Yeo A, Tan CH. Automated assessment of thigh composition using machine learning for Dixon magnetic resonance images. Magnetic Resonance Materials in Physics, Biology and Medicine. 2016;29(5):723-31.
Yeo C, Lim WS, Chan M, Ho XQ, Anthony PV, Han HC, Chong MS. Severe Impairment Rating Scale: A Useful and Brief Cognitive Assessment Tool for Advanced Dementia for Nursing Home Residents. American Journal of Alzheimer’s Disease & Other Dementias. 2016;31(1):87-96.
Zhao YJ, Lin L, Zhou HJ, Tan KT, Chew AP, Foo CG, …, Lim WS. Cost-effectiveness modelling of novel oral anticoagulants incorporating real-world elderly patients with atrial fibrillation. International Journal Cardiology. 2016;220:794-801.

Abisheganaden J, Ding YY, Chong WF, Heng BH, Verma A, Lim TK. Health-Care Associated Pneumonia (HCAP): Identification of Low and High-Risk Patients. Current Respiratory Medicine Reviews. 2015;11(3):241-6. doi: 10.1016/j.ajem.2008.03.015
Cheong CY, Merchant RA, Ngiam NS, Lim WS. Facilitated simulated patient sessions in mental-state examination teaching. Medical education. 2015;49(11):1147-8. doi:10.1111/medu.12846
Cheung YB, Xu Y, Feng L, Nyunt MS, Chong MS, Lim WS, et al. Unconditional and Conditional Standards Using Cognitive Function Curves for the Modified Mini-Mental State Exam: Cross-Sectional and Longitudinal Analyses in Older Chinese Adults in Singapore. The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry. 2015;23(9):915-24. doi:10.1016/j.jagp.2014.08.008
Chew J, Chong MS, Fong YL, Tay L. Outcomes of a multimodal cognitive and physical rehabilitation program for persons with mild dementia and their caregivers: a goal-oriented approach. Clinical interventions in aging. 2015;10:1687-94. doi:10.2147/cia.s93914
Chong MS, Tay L, Chan M, Lim WS, Ye R, Tan EK, Ding YY. Prospective longitudinal study of frailty transitions in a community-dwelling cohort of older adults with cognitive impairment. BMC Geriatrics. 2015;15(1):175. doi:10.1186/s12877-015-0174-1
Chong MS, Tay L, Ismail NH, Tan CH, Yew S, Yeo A, …, Ding YY. The Case for Stage-Specific Frailty Interventions Spanning Community Aging to Cognitive Impairment. Journal of the American Medical Directors Association. 2015;16(11):1003.e13–.e19. doi:10.1016/j.jamda.2015.08.025
Ding YY, Kader B, Christiansen CL, Berlowitz DR. Hemoglobin Level and Hospital Mortality Among ICU Patients With Cardiac Disease Who Received Transfusions. Journal of the American College of Cardiology. 2015;66(22):2510-8. doi:10.1016/j.jacc.2015.09.057
Goh LK, Lim WS, Teo S, Vijayaraghavan A, Chan M, Tay L, …, Chong MS. TOMM40 alterations in Alzheimer's disease over a 2-year follow-up period. Journal of Alzheimer's disease. 2015;44(1):57-61. doi:10.3233/jad-141590
Koh GC, Ling CL, Ma BH, Chen C, Lim WS, Scherer SC, et al. Effect of a new longitudinal interprofessional geriatric medicine educational track on knowledge and attitude of medical students: a controlled cohort study. Journal of the American Geriatrics Society. 2015;63(3):558-64. doi:10.1111/jgs.13295
Lau S, Chong MS, Ali N, Chan M, Chua KC, Lim WS. Caregiver Burden: Looking Beyond the Unidimensional Total Score. Alzheimer disease and associated disorders. 2015;29(4):338-46. doi:10.1097/wad.0000000000000085
Lim JP, Leung BP, Ding YY, Tay L, Ismail NH, Yeo A, …, Chong MS. Monocyte chemoattractant protein-1: a proinflammatory cytokine elevated in sarcopenic obesity. Clinical interventions in aging. 2015;10:605-9. doi:10.2147/cia.s78901
Lim JP, Li I, Lim WS. Memantine-Induced Myoclonus Precipitated by Renal Impairment and Drug Interactions. Journal of the American Geriatrics Society. 2015;63(12):2643-4. doi:10.1111/jgs.13847
Lim WS, Ding YY. Evidence-balanced medicine: "real" evidence-based medicine in the elderly. Annals of the Academy of Medicine, Singapore. 2015;44(1):1-5.
Lin L, Lim WS, Zhou HJ, Khoo AL, Tan KT, Chew AP, …, Chin JJ, et al. Clinical and Safety Outcomes of Oral Antithrombotics for Stroke Prevention in Atrial Fibrillation: A Systematic Review and Network Meta-analysis. Journal of the American Medical Directors Association. 2015;16(12):1103.e1-.e19. doi:10.1016/j.jamda.2015.09.008
Loo B, Chew J, Sridevi S. Pilot Programme on Animal-Assisted Therapy in Singapore. Proceedings of Singapore Healthcare. 2015;24(2):113-6. doi:10.1177/201010581502400207
Ng TP, Feng L, Lim WS, Chong MS, Lee TS, Yap KB, et al. Montreal Cognitive Assessment for screening mild cognitive impairment: variations in test performance and scores by education in Singapore. Dementia and geriatric cognitive disorders. 2015;39(3-4):176-85. doi:10.1159/000368827
Seng WR, Belani MH, Ramason R, Naidu G, Doshi HK. Functional Improvement in Geriatric Hip Fractures: Does Vitamin D Deficiency Affect the Functional Outcome of Patients With Surgically Treated Intertrochanteric Hip Fractures. Geriatric Orthopaedic Surgery & Rehabilitation. 2015;6(3):186-91. doi:10.1177/2151458515584639
Tay L, Ding YY, Leung BP, Ismail NH, Yeo A, Yew S, …, Chong MS. Sex-specific differences in risk factors for sarcopenia amongst community-dwelling older adults. Age (Dordrecht, Netherlands). 2015;37(6):121. doi:10.1007/s11357-015-9860-3
Tay L, Lim WS, Chan M, Ali N, Mahanum S, Chew P, …, Chong MS. New DSM-V neurocognitive disorders criteria and their impact on diagnostic classifications of mild cognitive impairment and dementia in a memory clinic setting. The American Journal of Geriatric Psychiatry. 2015;23(8):768-79. doi:10.1016/j.jagp.2015.01.004
Veronese N, Cereda E, Solmi M, Fowler SA, Manzato E, Maggi S, …, Chan M, et al. Inverse relationship between body mass index and mortality in older nursing home residents: a meta-analysis of 19,538 elderly subjects. Obesity reviews: an official journal of the International Association for the Study of Obesity. 2015;16(11):1001-15. doi:10.1111/obr.12309

Chong MS, Chan M, Tay L, Ding YY. Outcomes of an innovative model of acute delirium care: the Geriatric Monitoring Unit (GMU). Clinical interventions in aging. 2014;9:603-12. doi:10.2147/cia.s60259
Chong MS, Tay L, Chan M, Lim WS, Ye R, Wong WC, Lim JP, Tan EK, Ding YY. Stage-Specific Relationship between Frailty and Cognitive Impairment in a Specialist Memory Clinic Setting. The Journal of frailty & aging. 2014;3(2):113-9.
Doshi HK, Ramason R, Azellarasi J, Chan WL, Naidu G. Functional improvement of self-care in the elderly after hip fracture: is age a factor? Archives of orthopaedic and trauma surgery. 2014;134(4):489-93. doi:10.14283/jfa.2014.11
Doshi HK, Ramason R, Azellarasi J, Naidu G, Chan WL. Orthogeriatric model for hip fracture patients in Singapore: our early experience and initial outcomes. Archives of orthopaedic and trauma surgery. 2014;134(3):351-7. doi:10.1007/s00402-014-1924-9
Lam CY, Tay L, Chan M, Ding YY, Chong MS. Prospective observational study of delirium recovery trajectories and associated short-term outcomes in older adults admitted to a specialized delirium unit. Journal of the American Geriatrics Society. 2014;62(9):1649-57.
Lim WS, Cheah WK, Ali N, Han HC, Anthony PV, Chan M, Chong MS. Worry about performance: a unique dimension of caregiver burden. International psychogeriatrics. 2014;26(4):677-86. doi:10.1111/jgs.12995 doi:10.1017/s1041610213002445
Ramason R, Chong MS, Chan W, Rajamoney GN. Innovations in Hip Fracture Care: A Comparison of Geriatric Fracture Centers. Journal of the American Medical Directors Association. 2014;15(4):232-3. doi:10.1016/j.jamda.2014.01.005
Ramason R, Selvaganapathi N, Ismail NH, Wong WC, Rajamoney GN, Chong MS. Prevalence of Vitamin D Deficiency in Patients with Hip Fracture Seen in an Orthogeriatric Service in Sunny Singapore. Geriatric Orthopaedic Surgery & Rehabilitation. 2014;5(2):82-6. doi:10.1177/2151458514528952
Tan KT, Adzhahar FB, Lim I, Chan M, Lim WS. Transactive memory system as a measure of collaborative practice in a geriatrics team: implications for continuing interprofessional education. Journal of interprofessional care. 2014;28(3):239-45. doi:10.3109/13561820.2014.901938
Tay L, Chua KC, Chan M, Lim WS, Ang YY, Koh E, Chong MS. Differential perceptions of quality of life (QoL) in community-dwelling persons with mild-to-moderate dementia. International psychogeriatrics. 2014;26(8):1273-82. doi:10.1017/s1041610214000660

Chong MS, Goh LK, Lim WS, Chan M, Tay L, Chen G, et al. Gene expression profiling of peripheral blood leukocytes shows consistent longitudinal downregulation of TOMM40 and upregulation of KIR2DL5A, PLOD1, and SLC2A8 among fast progressors in early Alzheimer's disease. Journal of Alzheimer's disease. 2013;34(2):399-405. doi:10.3233/jad-121621
Chong MS, Tan KT, Tay L, Wong YM, Ancoli-Israel S. Bright light therapy as part of a multicomponent management program improves sleep and functional outcomes in delirious older hospitalized adults. Clinical interventions in aging. 2013;8:565-72. doi:10.2147/cia.s44926
Chong MS, Tan WS, Chan M, Lim WS, Ali N, Ang YY, et al. Cost of informal care for community-dwelling mild-moderate dementia patients in a developed Southeast Asian country. International psychogeriatrics. 2013;25(9):1475-83.  doi:10.1017/s1041610213000707
Ding YY, Abisheganaden J, Chong WF, Heng BH, Lim TK. Effectiveness of acute geriatric units in the real world: the case of short-term mortality among seniors hospitalized for pneumonia. Geriatrics & gerontology international. 2013;13(1):55-62. doi:10.1111/j.1447-0594.2012.00858.x
Feng L, Chong MS, Lim WS, Lee TS, Collinson SL, Yap P, et al. Metabolic syndrome and amnestic mild cognitive impairment: Singapore Longitudinal Ageing Study-2 findings. Journal of Alzheimer's disease. 2013;34(3):649-57. doi:10.3233/jad-121885
Nagaendran K, Chen LH, Chong MS, Chua EV, Goh CK, Kua J…, Lim WS, et al . Ministry of health clinical practice guidelines: dementia. Singapore medical journal. 2013;54(5):293-8. doi:10.11622/smedj.2013112
Neo HY, Tan KT, Ding YY. Higher than expected rates of seizures associated with the use of ertapenem in older hospitalized patients. Journal of Clinical Gerontology and Geriatrics. 2013;4(1):17-21. doi:10.1016/j.jcgg.2012.09.004
Nyunt MS, Chong MS, Lim WS, Lee TS, Yap P, Ng TP. Reliability and Validity of the Clinical Dementia Rating for Community-Living Elderly Subjects without an Informant. Dementia and geriatric cognitive disorders extra. 2013;3(1):407-16. doi:10.1159/000355122
Tay L, Chan M, Chong MS. Functional improvement in hospitalized older adults is independent of dementia diagnosis: experience of a specialized delirium management unit. Journal of hospital medicine. 2013;8(6):321-7. doi:10.1002/jhm.2035
Ting SK, Chong MS, Kandiah N, Hameed S, Tan L, Au WL, et al. Absence of A673T amyloid-beta precursor protein variant in Alzheimer's disease and other neurological diseases. Neurobiology of aging. 2013;34(10):2441.e7-.e8. doi:10.1016/j.neurobiolaging.2013.04.012

Special Issue: Dementia, Frailty and Aging

Welcome to this issue under Frontiers in Medicine which blends nicely with our research focuses of ageing brain (dementia) and frailty. This collection of 14 articles runs the gamut from insights in interface between cognition and physical domains, through to pertinent areas of caregiving and diagnosis in dementia, and evolving areas such as big data and microbes theory in brain ageing.

Find out more about the articles from here: