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Research Publications

Notwithstanding competing challenges from their clinical, educator and administrator roles, our clinicians have been heavily involved in a wide range of research and publishing steadily over the past years. Multi- and interdisciplinary collaborations with both local and international researchers have propelled IGA further in our growth.


Cabradilla J, Ong PL, Villaverde E, Marasigan E, Declarador N, Tan KT, Tan HN, Ding YY. The Safety of Treatment with Cefepime in Elderly Patients. Aging Medicine and Healthcare. 2019;10:139-45.
Chan EY, Lim ZX, Ding YY, Chan YH, Lim WS. Development of a Brief Caregiver-centric Screening Tool to Identify Risk of Depression among Caregivers of Hospitalized Older Adults. Journal of Nutrition, Health and Aging. 2019;23(6):578-85.
Chan EY, Phang KN, Glass GFJ, Lim WS. Crossing, Trudging and Settling: A phenomenological inquiry into lived experience of Asian family caregivers of older persons with dementia. Geriatrics Nursing. 2019;23.
Cheong TS, Goh WY, Ong EH, Abdul-Karim SN, See LL, Chong E. The Prevalence of Frailty and Its Association with Adverse Drug Reactions in Hospitalized Older Adults. Journal of Geriatric Medicine and Gerontology. 2019;5(3):8.
Chew BH, Tang CJ, Lim WS, Yap J, Zhou W, Liaw SY. Interprofessional bedside rounds: Nurse-physician collaboration and perceived barriers in an Asian hospital. Journal of interprofessional care. 2019:1-3.
Chew J, Tay L, Lim JP, Leung BP, Yeo A, Yew S, Ding YY, Lim WS. Serum Myostatin and IGF-1 as Gender-Specific Biomarkers of Frailty and Low Muscle Mass in Community-Dwelling Older Adults. The Journal of Nutrition, Health and Ageing. 2019;23(10):979-86.
Chong E, Chia JQ, Law F, Chew J, Chan M, Lim WS. Validating a Standardised Approach in Administration of the Clinical Frailty Scale in Hospitalised Older Adults. Annals of the Academy of Medicine, Singapore. 2019;48(4):115-24.
Heyzer L, Ali N, Chew AP, Chan M, Lim WS. Worry about Performance: Unravelling the Relationship between 'Doing More' and 'Doing Better'. The Journal of Nutrition, Health and Aging. 2019;23(9):843-8.
Hum A, Tay RY, Wong Y, Ali N, Leong I, Wu HY, Chin JJ, Lee A, Koh M. Advanced dementia: an integrated homecare programme. BMJ Supportive & Palliative Care. 2019.
Hum A, Wong Y, Yee CM, Lee CS, Wu HY, Koh M. PROgnostic Model for Advanced Cancer (PRO-MAC). BMJ Supportive & Palliative Care. 2019.
Khor E, Lim JP, Tay L, Yeo A, Yew S, Ding YY, Lim WS. Obesity Definitions in Sarcopenic Obesity: Differences in Prevalence, Agreement and Association with Muscle Function. The Journal of frailty & aging. 2019.
Koh M, Hum A, Khoo HS, Ho A, Chong PH, Ong WY, et al. Burnout and Resilience After a Decade in Palliative Care: What Survivors Have to Teach Us. A Qualitative Study of Palliative Care Clinicians With More Than 10 Years of Experience. Journal of Pain Symptom Management. 2020;59(1):105-15.
Koh M, Lee JF, Montalban S, Foo CL, Hum A. ED-PALS: A Comprehensive Palliative Care Service for Oncology Patients in the Emergency Department. American Journal of Hospital and Palliative Care. 2019;36(7):571-6.
Lau S, Ali N, Lim JP, Lim WS. ZBI multidimensionality: The salience of worry about performance. International psychogeriatrics. 2019;31(6):909-11.
Lim JP, Chong MS, Tay L, Yang YX, Leung BP, Yeo A, …, Lim WS. Inter-muscular adipose tissue is associated with adipose tissue inflammation and poorer functional performance in central adiposity. Archives of Gerontology and Geriatrics. 2019;81:1-7.
Lim WS, Chew J, Lim JP, Tay L, Ismail NH, Ding YY. Case for Validated Instead of Standard Cut-Offs for SARC-CalF. The Journal of Nutrition, Health and Aging. 2019;23(4):393-5.
Lim WS, Tham KM, Adzahar FB, Neo HY, Wong WC, Lim I, et al. Trends of clarification purpose of medical education research in the Asia-Pacific region: A scoping review. The Asia Pacific Scholar. 2019;4(1):24-33.
Lim WS, Wong CH, Ding YY, Rockwood K, Lien C. Translating the Science of Frailty in Singapore: Results from the National Frailty Consensus Discussion. Annals of the Academy of Medicine, Singapore. 2019;48(1):25-31.
Lin CP, Cheng SY, Mori M, Suh SY, Chan HY, Martina D, …, Ng HLR, et al. 2019 Taipei Declaration on Advance Care Planning: A Cultural Adaptation of End-of-Life Care Discussion. Journal of Palliative Medicine. 2019;22(10):1175-7.
Neo HY, Tan KT, Caroline C, Ng D, Ho E, Lim JP, Lee R, …, Ding YY. Higher rates of carbapenem-related seizures in older hospitalised adults. Internal Medicine Journal. 2020;50(1):123-7.
Ng I, Tey J, Chia D, Yee CM, Cheo T. A review of whole brain radiotherapy outcomes in a high epidermal growth factor receptor mutation rate population: Does QUARTZ apply in Asia? Asia-Pacific Journal of Clinical Oncology. 2019;15(6):353-7.
Tan GP, Soon L, Ni B, Cheng H, Tan A, Kor AC, et al. The pattern of use and survival outcomes of a dedicated adult Home Ventilation and Respiratory Support Service in Singapore: a 7-year retrospective observational cohort study. Journal of Thoracic Disease. 2019;11(3):795-804.
Tay M, Tham SL. Oropharyngeal recovery in a patient with the pharyngeal cervical brachial variant of Guillain-Barré syndrome. The Journal of the International Society of Physical and Rehabilitation Medicine. 2019;2(2):100-3.
Tay M, Soh YM, Plunkett TK, Ong PL, Huang W, Kong KH. The Validity of the Montreal Cognitive Assessment for Moderate to Severe Traumatic Brain Injury Patients: A Pilot Study. American Journal of Physical Medicine & Rehabilitation. 2019;98(11):971-5.
Tay RY, Hum A, Ali N, Leong I, Wu HY, Chin JJ, …, Koh M. Comfort and Satisfaction with Care of Home-Dwelling Dementia Patients at the End of Life. Journal of Pain Symptom Management. 2019.
Tham SL, Kong KH. Impact of a week-long physical medicine and rehabilitation clerkship on rehabilitation knowledge of the 3rd -Year medical students in Singapore. The Journal of the International Society of Physical and Rehabilitation Medicine. 2019;2:42-46.


Chan EY, Glass G, Chua KC, Ali N, Lim WS. Relationship between Mastery and Caregiving Competence in Protecting against Burden, Anxiety and Depression among Caregivers of Frail Older Adults. The Journal of Nutrition, Health and Aging. 2018;22(10):1238-45.
Cheong TS, Goh WY, Ong EH, Abdul-Karim SN, See LL, Chong E. The Prevalence of Frailty and Its Association with Adverse Drug Reactions in Hospitalized Older Adults. Journal of Geriatric Medicine and Gerontology. 2019;5(3):8.
Chong E, Chan M, Lim WS, Ding YY. Frailty Predicts Incident Urinary Incontinence Among Hospitalized Older Adults-A 1-Year Prospective Cohort Study. Journal of the American Medical Directors Association. 2018;19(5):422-7.
Chong E, Chan M, Lim WS, Ding YY. Response to the Letter to the Editor: Flaws Related to the Article Entitled "Frailty Predicts Incident Urinary Incontinence Among Hospitalized Older Adults". Journal of the American Medical Directors Association. 2018;19(11):1020-1.
Chong E, Ho E, Baldevarona-Llego J, Chan M, Wu L, Tay L, Ding YY, Lim WS. Frailty in Hospitalized Older Adults: Comparing Different Frailty Measures in Predicting Short- and Long-term Patient Outcomes. Journal of the American Medical Directors Association. 2018;19(5):450-7.e3.
Chong MS, Tan CN, Yew S, Lim JP, Lim WS, Lieu PK. Successful Ageing in Nonagenarians: Bio-psychosocial Factors Determining Successful Ageing in Long-Lived Older Adults. Journal of the American Medical Directors Association. 2018;19(1):90-2.
Declarador N, Ramason R, Tay L, Chan W, Kwek E. Beyond comanaged inpatient care to community integration: Factors leading to surgical delay in hip fractures and their associated outcomes. Journal of orthopaedic surgery (Hong Kong). 2018;26(2):2309499018783909.
Gao Q, Gwee X, Feng L, Nyunt MS, Collinson SL, Chong MS, Lim WS, et al. Mild Cognitive Impairment Reversion and Progression: Rates and Predictors in Community-Living Older Persons in the Singapore Longitudinal Ageing Studies Cohort. Dementia and Geriatric Cognitive Disorders Extra 2018;8(2):226-37.
Kua J, Chan M, See J, Ng D, Lim WS. STarDom study - Applying systems theory framework for Internal Medicine senior residency career development in a Singapore ACGMEI Residency Programme. The Asia-Pacific Scholar. 2018;3(2):6-18.
Kumar R, Teo EK, How CH, Wong TY, Ang TL. A practical clinical approach to liver fibrosis. Singapore medical journal. 2018;59(12):628-33.
Li J, Cesari M, Del Campo N, Andrieu S, Dong B, Lim WS, et al. Impact of diabetes on caregiver stress in patients with Alzheimer's disease: data from the ICTUS study. International psychogeriatrics. 2018;30(8):1109-17.
Li R, Chong MS, Chan M, Tay L, Ali N, Lim WS. Worry About Caregiving Performance: A Confirmatory Factor Analysis. Frontiers in Medicine. 2018;5:79.
Liaw SY, Carpio GAC, Lau Y, Tan SC, Lim WS, Goh PS. Multiuser virtual worlds in healthcare education: A systematic review. Nurse education today. 2018;65:136-49.
Lim JP, Chong MS, Tay L, Yang YX, Leung BP, Yeo A, …, Lim WS. Inter-muscular adipose tissue is associated with adipose tissue inflammation and poorer functional performance in central adiposity. Archives of Gerontology and Geriatrics. 2018;81:1-7.
Lim WS, Canevelli M, Cesari M. Editorial: Dementia, Frailty and Aging. Frontiers in Medicine. 2018;5:168.
Lim WS, Tay L, Yeo A, Yew S, Hafizah N, Ding YY. Modulating Effect of Contextual Factors on Factor Structure and Reliability of SARC-F. Journal of the American Medical Directors Association. 2018;19(6):551-3.
Loo ME, Krishnasamy C, Lim WS. Considering Face, Rights, and Goals: A Critical Review of Rapport Management in Facilitator-Guided Simulation Debriefing Approaches. Simulation in healthcare : journal of the Society for Simulation in Healthcare. 2018;13(1):52-60.
Malhotra R, Bautista MAC, Muller AM, Aw S, Koh G, Theng YL…, Lim WS, et al. The Aging of a Young Nation: Population Aging in Singapore. The Gerontologist. 2018.
Tay L, Leung BP, Wee S, Tay KS, Ali N, Chan M, Lim WS. Association of nutrition and immune-endocrine dysfunction with muscle mass and performance in cognitively impaired older adults. Archives of Gerontology and Geriatrics. 2018;75:20-7.
Wong J, Archarya R, Kwang HM, Kam YT, Tan E, Ting J, Lim WS. SimRound, A novel approach to transitions of Junior Medical Students into Clinical Clerkships: Rationale, Development and Lessons Learnt. MedEdPublish. 2018;7:40.


Abengana J, Chong MS, Tay L. Delirium superimposed on dementia: phenomenological differences between patients with and without behavioral and psychological symptoms of dementia in a specialized delirium unit. International Psychogeriatrics. 2017;29(3):485-95.
Ch'ng A, Yong K, Ng D, Heyzer L, Lim WS. Trends in Geriatrics-Related Translational Research and Funding in the "Big 4" Medical Journals. Journal of the American Medical Directors Association. 2017;18(6):544-5.
Chew J, Lim WS, Chong MS, Ding YY, Tay L. Impact of frailty and residual subsyndromal delirium on 1-year functional recovery: A prospective cohort study. Geriatrics and Gerontology International. 2017;17(12):2472-8.
Chong E, Ho E, Baldevarona-Llego J, Chan M, Wu L, Tay L. Frailty and Risk of Adverse Outcomes in Hospitalized Older Adults: A Comparison of Different Frailty Measures. Journal of the American Medical Directors Association. 2017;18(7):638.e7-.e11.
Chong E, Ho E, Baldevarona-Llego J, Chan M, Wu L, Tay L, Ding YY, Lim WS. Frailty in Hospitalized Older Adults: Comparing Different Frailty Measures in Predicting Short- and Long-term Patient Outcomes. Journal of the American Medical Directors Association. 2018;19(5):450-7.e3.
Dent E, Lien C, Lim WS, Wong WC, Wong CH, Ng TP, et al. The Asia-Pacific Clinical Practice Guidelines for the Management of Frailty. Journal of the American Medical Directors Association. 2017;18(7):564-75.
Ding YY. Predictive Validity of Two Physical Frailty Phenotype Specifications Developed for Investigation of Frailty Pathways in Older People. Gerontology. 2017;63(5):401-10.
Ding YY, Kuha J, Murphy M. Multidimensional predictors of physical frailty in older people: identifying how and for whom they exert their effects. Biogerontology. 2017;18(2):237-52.
Ding YY, Kuha J, Murphy M. Pathways from physical frailty to activity limitation in older people: Identifying moderators and mediators in the English Longitudinal Study of Ageing. Experimental Gerontology. 2017;98:169-76.
Feng L, Lim WS, Chong MS, Lee TS, Gao Q, Nyunt MS, et al. Depressive Symptoms Increase the Risk of Mild Neurocognitive Disorders among Elderly Chinese. The Journal of Nutrition, Health and Aging. 2017;21(2):161-4.
Feng L, Nyunt MS, Gao Q, Lee TS, Tsoi T, Chong MS, Lim WS, et al. Physical Frailty, Cognitive Impairment, and the Risk of Neurocognitive Disorder in the Singapore Longitudinal Ageing Studies. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2017;72(3):369-75.
Haider A, Zhukovsky DS, Yee CM, Baidoo J, Tanco KC, Stewart HA, et al. Opioid Prescription Trends Among Patients With Cancer Referred to Outpatient Palliative Care Over a 6-Year Period. Journal of Oncology Practice. 2017;13(12):e972-e81.
Heywood R, Gao Q, Nyunt MS, Feng L, Chong MS, Lim WS, et al. Hearing Loss and Risk of Mild Cognitive Impairment and Dementia: Findings from the Singapore Longitudinal Ageing Study. Dementia and Geriatric Cognitive Disorders. 2017;43(5-6):259-68.
Koh M, Hum A, Xiang WW. Clinical Variety May Help Prevent Burnout After a Decade in Palliative Care. Journal of Pain and Symptom Management. 2017;55(2):e3-e5.
Koh ZY, Lim S, Lim WS. An Interesting Case of "Refractory" Hypomagnesemia. Journal of the American Medical Directors Association. 2017;18(7):632-3.
Lim WS, Tham KM, Adzahar FB, Neo HY, Wong WC, Ringsted C. Determinants of clarification research purpose in medical education research: A systematic review. The Aisa-Pacific Scholar. 2017;2(2):8-17.
Lim WS, Wong SF, Leong I, Choo P, Pang WS. Forging a Frailty-Ready Healthcare System to Meet Population Ageing. International Journal Environmental Research and Public Health. 2017;14(12):E1448.
Neo HY, Xu HY, Wu HY, Hum A. Prediction of Poor Short-Term Prognosis and Unmet Needs in Advanced Chronic Obstructive Pulmonary Disease: Use of the Two-Minute Walking Distance Extracted from a Six-Minute Walk Test. Journal of Palliative Medicine. 2017;20(8):821-8.
Nyunt MS, Soh CY, Gao Q, Gwee X, Ling A, Lim WS, et al. Characterisation of Physical Frailty and Associated Physical and Functional Impairments in Mild Cognitive Impairment. Frontiers in Medicine. 2017;4(18):230.
Ong SY, Tan N, Knab MS, Farrell SE, Lim WS. Attitudes of clinician educators towards interprofessional education and collaboration: Insights from two interprofessional scales. Journal of interprofessional care. 2017;31(5):656-60.
Rawtaer I, Gao Q, Nyunt MS, Feng L, Chong MS, Lim WS, et al. Psychosocial Risk and Protective Factors and Incident Mild Cognitive Impairment and Dementia in Community Dwelling Elderly: Findings from the Singapore Longitudinal Ageing Study. American Journal of Alzheimers Disease and Other Dementias. 2017;57(2):603-11.
Teo WL, Lee M, Lim WS. The relational activation of resilience model: How leadership activates resilience in an organizational crisis. Journal of Contingencies and Crisis Management. 2017;25:136-47.
Walsh K, Noben C, Gregory S, Lim WS, Green C, Roberts T, et al. Cost benefit analysis of healthcare professional education: report of a conference workshop. BMJ Simulation and Technology Enhanced Learning. 2017;4(2):95-6.
Win KK, Chong MS, Ali N, Chan M, Lim WS. Burden among Family Caregivers of Dementia in the Oldest-Old: An Exploratory Study. Frontiers in Medicine. 2017;4:205.
Yang YX, Chong MS, Lim WS, Tay L, Yew S, Yeo A, et al. Validity of estimating muscle and fat volume from a single MRI section in older adults with sarcopenia and sarcopenic obesity. Clinical Radiology. 2017;72(5):427.e9-.e14.
Yock Y, Lim I, Lim YH, Lim WS, Chew N, Archuleta S. Sometimes Means Some of the Time: Residents' Overlapping Responses to Vague Quantifiers on the ACGME-I Resident Survey. Journal of Graduate Medical Education. 2017;9(6):735-40.
Zhao YJ, Lim WS. Dabigatran Compared With Rivaroxaban vs Warfarin. JAMA Internal Medicine. 2017;177(5):742.


Chan CY, Sum MY, Lim WS, Chew NW, Samarasekera DD, Sim K. Adoption and correlates of Postgraduate Hospital Educational Environment Measure (PHEEM) in the evaluation of learning environments - A systematic review. Medical Teacher. 2016;38(12):1248-55.
Chew J, Cheong S, Tay L. Quetiapine-Induced Cutaneous Vasculitis: Diagnostic Challenges and Therapeutic Implications. Journal of American Geriatrics Society. 2016;64(5):1137-8.
Ding YY. Developing physical frailty specifications for investigation of frailty pathways in older people. Age (Dordrecht, Netherlands). 2016;38(2):47.
Feng L, Chong MS, Lim WS, Gao Q, Nyunt MS, Lee TS, et al. Tea Consumption Reduces the Incidence of Neurocognitive Disorders: Findings from the Singapore Longitudinal Aging Study. The Journal of Nutrition, Health and Aging. 2016;20(10):1002-9.
Kua J, Ramason R, Rajamoney G, Chong MS. Which frailty measure is a good predictor of early post-operative complications in elderly hip fracture patients? Archives of orthopaedic and trauma surgery. 2016;136(5):639-47.
Lee SY, Dong L, Lim YH, Poh CL, Lim WS. SBAR: towards a common interprofessional team-based communication tool. Medical education. 2016;50(11):1167-8.
Loke SC, Lim WS, Someya Y, Hamid TA, Nudin SSH. Examining the Disability Model From the International Classification of Functioning, Disability, and Health Using a Large Data Set of Community-Dwelling Malaysian Older Adults. Journal of Aging and Health. 2016;28(4):704-25.
Ng TP, Feng L, Nyunt MS, Feng L, Gao Q, Lim ML, …, Chong MS, Lim WS, et al. Metabolic Syndrome and the Risk of Mild Cognitive Impairment and Progression to Dementia: Follow-up of the Singapore Longitudinal Ageing Study Cohort. JAMA Neurology. 2016;73(4):456-63.
Ong YH, Lim I, Tan KT, Chan M, Lim WS. Assessing shared leadership in interprofessional team meetings: A validation study. The Asia Pacific Scholar. 2016;1(1):9-19.
Rawtaer I, Feng L, Yuen VH, Li J, Chong MS, Lim WS, et al. A Risk Score for the Prediction of Neurocognitive Disorders among Community-Dwelling Chinese Older Adults. Dementia and geriatric cognitive disorders. 2016;41(5-6):348-58.
Tay L, Lim WS, Chan M, Ali N, Chong MS. A Combined Cognitive Stimulation and Physical Exercise Programme (MINDVital) in Early Dementia: Differential Effects on Single- and Dual-Task Gait Performance. Gerontology. 2016;62(6):604-10.
Tay L, Lim WS, Chan M, Ye RJ, Chong MS. The Independent Role of Inflammation in Physical Frailty among Older Adults with Mild Cognitive Impairment and Mild-to-Moderate Alzheimer's Disease. The Journal of Nutrition, Health and Aging. 2016;20(3):288-99.
Yang YX, Chong MS, Tay L, Yew S, Yeo A, Tan CH. Automated assessment of thigh composition using machine learning for Dixon magnetic resonance images. Magnetic Resonance Materials in Physics, Biology and Medicine. 2016;29(5):723-31.
Yeo C, Lim WS, Chan M, Ho XQ, Anthony PV, Han HC, Chong MS. Severe Impairment Rating Scale: A Useful and Brief Cognitive Assessment Tool for Advanced Dementia for Nursing Home Residents. American Journal of Alzheimer’s Disease & Other Dementias. 2016;31(1):87-96.
Zhao YJ, Lin L, Zhou HJ, Tan KT, Chew AP, Foo CG, …, Lim WS. Cost-effectiveness modelling of novel oral anticoagulants incorporating real-world elderly patients with atrial fibrillation. International Journal Cardiology. 2016;220:794-801.


Abisheganaden J, Ding YY, Chong WF, Heng BH, Verma A, Lim TK. Health-Care Associated Pneumonia (HCAP): Identification of Low and High-Risk Patients. Current Respiratory Medicine Reviews. 2015;11(3):241-6.
Cheong CY, Merchant RA, Ngiam NS, Lim WS. Facilitated simulated patient sessions in mental-state examination teaching. Medical education. 2015;49(11):1147-8.
Cheung YB, Xu Y, Feng L, Nyunt MS, Chong MS, Lim WS, et al. Unconditional and Conditional Standards Using Cognitive Function Curves for the Modified Mini-Mental State Exam: Cross-Sectional and Longitudinal Analyses in Older Chinese Adults in Singapore. The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry. 2015;23(9):915-24.
Chew J, Chong MS, Fong YL, Tay L. Outcomes of a multimodal cognitive and physical rehabilitation program for persons with mild dementia and their caregivers: a goal-oriented approach. Clinical interventions in aging. 2015;10:1687-94.
Chong MS, Tay L, Chan M, Lim WS, Ye R, Tan EK, Ding YY. Prospective longitudinal study of frailty transitions in a community-dwelling cohort of older adults with cognitive impairment. BMC Geriatrics. 2015;15(1):175.
Chong MS, Tay L, Ismail NH, Tan CH, Yew S, Yeo A, …, Ding YY. The Case for Stage-Specific Frailty Interventions Spanning Community Aging to Cognitive Impairment. Journal of the American Medical Directors Association. 2015;16(11):1003.e13–.e19.
Ding YY, Kader B, Christiansen CL, Berlowitz DR. Hemoglobin Level and Hospital Mortality Among ICU Patients With Cardiac Disease Who Received Transfusions. Journal of the American College of Cardiology. 2015;66(22):2510-8.
Goh LK, Lim WS, Teo S, Vijayaraghavan A, Chan M, Tay L, …, Chong MS. TOMM40 alterations in Alzheimer's disease over a 2-year follow-up period. Journal of Alzheimer's disease. 2015;44(1):57-61.
Koh GC, Ling CL, Ma BH, Chen C, Lim WS, Scherer SC, et al. Effect of a new longitudinal interprofessional geriatric medicine educational track on knowledge and attitude of medical students: a controlled cohort study. Journal of the American Geriatrics Society. 2015;63(3):558-64.
Lau S, Chong MS, Ali N, Chan M, Chua KC, Lim WS. Caregiver Burden: Looking Beyond the Unidimensional Total Score. Alzheimer disease and associated disorders. 2015;29(4):338-46.
Lim JP, Leung BP, Ding YY, Tay L, Ismail NH, Yeo A, …, Chong MS. Monocyte chemoattractant protein-1: a proinflammatory cytokine elevated in sarcopenic obesity. Clinical interventions in aging. 2015;10:605-9.
Lim JP, Li I, Lim WS. Memantine-Induced Myoclonus Precipitated by Renal Impairment and Drug Interactions. Journal of the American Geriatrics Society. 2015;63(12):2643-4.
Lim WS, Ding YY. Evidence-balanced medicine: "real" evidence-based medicine in the elderly. Annals of the Academy of Medicine, Singapore. 2015;44(1):1-5.
Lin L, Lim WS, Zhou HJ, Khoo AL, Tan KT, Chew AP, …, Chin JJ, et al. Clinical and Safety Outcomes of Oral Antithrombotics for Stroke Prevention in Atrial Fibrillation: A Systematic Review and Network Meta-analysis. Journal of the American Medical Directors Association. 2015;16(12):1103.e1-.e19.
Loo B, Chew J, Sridevi S. Pilot Programme on Animal-Assisted Therapy in Singapore. Proceedings of Singapore Healthcare. 2015;24(2):113-6.
Ng TP, Feng L, Lim WS, Chong MS, Lee TS, Yap KB, et al. Montreal Cognitive Assessment for screening mild cognitive impairment: variations in test performance and scores by education in Singapore. Dementia and geriatric cognitive disorders. 2015;39(3-4):176-85.
Seng WR, Belani MH, Ramason R, Naidu G, Doshi HK. Functional Improvement in Geriatric Hip Fractures: Does Vitamin D Deficiency Affect the Functional Outcome of Patients With Surgically Treated Intertrochanteric Hip Fractures. Geriatric Orthopaedic Surgery & Rehabilitation. 2015;6(3):186-91.
Tay L, Ding YY, Leung BP, Ismail NH, Yeo A, Yew S, …, Chong MS. Sex-specific differences in risk factors for sarcopenia amongst community-dwelling older adults. Age (Dordrecht, Netherlands). 2015;37(6):121.
Tay L, Lim WS, Chan M, Ali N, Mahanum S, Chew P, …, Chong MS. New DSM-V neurocognitive disorders criteria and their impact on diagnostic classifications of mild cognitive impairment and dementia in a memory clinic setting. The American Journal of Geriatric Psychiatry. 2015;23(8):768-79.
Veronese N, Cereda E, Solmi M, Fowler SA, Manzato E, Maggi S, …, Chan M, et al. Inverse relationship between body mass index and mortality in older nursing home residents: a meta-analysis of 19,538 elderly subjects. Obesity reviews: an official journal of the International Association for the Study of Obesity. 2015;16(11):1001-15.


Chong MS, Chan M, Tay L, Ding YY. Outcomes of an innovative model of acute delirium care: the Geriatric Monitoring Unit (GMU). Clinical interventions in aging. 2014;9:603-12.
Chong MS, Tay L, Chan M, Lim WS, Ye R, Wong WC, Lim JP, Tan EK, Ding YY. Stage-Specific Relationship between Frailty and Cognitive Impairment in a Specialist Memory Clinic Setting. The Journal of frailty & aging. 2014;3(2):113-9.
Doshi HK, Ramason R, Azellarasi J, Chan WL, Naidu G. Functional improvement of self-care in the elderly after hip fracture: is age a factor? Archives of orthopaedic and trauma surgery. 2014;134(4):489-93.
Doshi HK, Ramason R, Azellarasi J, Naidu G, Chan WL. Orthogeriatric model for hip fracture patients in Singapore: our early experience and initial outcomes. Archives of orthopaedic and trauma surgery. 2014;134(3):351-7.
Lam CY, Tay L, Chan M, Ding YY, Chong MS. Prospective observational study of delirium recovery trajectories and associated short-term outcomes in older adults admitted to a specialized delirium unit. Journal of the American Geriatrics Society. 2014;62(9):1649-57.
Lim WS, Cheah WK, Ali N, Han HC, Anthony PV, Chan M, Chong MS. Worry about performance: a unique dimension of caregiver burden. International psychogeriatrics. 2014;26(4):677-86.
Ramason R, Chong MS, Chan W, Rajamoney GN. Innovations in Hip Fracture Care: A Comparison of Geriatric Fracture Centers. Journal of the American Medical Directors Association. 2014;15(4):232-3.
Ramason R, Selvaganapathi N, Ismail NH, Wong WC, Rajamoney GN, Chong MS. Prevalence of Vitamin D Deficiency in Patients with Hip Fracture Seen in an Orthogeriatric Service in Sunny Singapore. Geriatric Orthopaedic Surgery & Rehabilitation. 2014;5(2):82-6.
Tan KT, Adzhahar FB, Lim I, Chan M, Lim WS. Transactive memory system as a measure of collaborative practice in a geriatrics team: implications for continuing interprofessional education. Journal of interprofessional care. 2014;28(3):239-45.
Tay L, Chua KC, Chan M, Lim WS, Ang YY, Koh E, Chong MS. Differential perceptions of quality of life (QoL) in community-dwelling persons with mild-to-moderate dementia. International psychogeriatrics. 2014;26(8):1273-82.



Chong MS, Goh LK, Lim WS, Chan M, Tay L, Chen G, et al. Gene expression profiling of peripheral blood leukocytes shows consistent longitudinal downregulation of TOMM40 and upregulation of KIR2DL5A, PLOD1, and SLC2A8 among fast progressors in early Alzheimer's disease. Journal of Alzheimer's disease. 2013;34(2):399-405.
Chong MS, Tan KT, Tay L, Wong YM, Ancoli-Israel S. Bright light therapy as part of a multicomponent management program improves sleep and functional outcomes in delirious older hospitalized adults. Clinical interventions in aging. 2013;8:565-72.
Chong MS, Tan WS, Chan M, Lim WS, Ali N, Ang YY, et al. Cost of informal care for community-dwelling mild-moderate dementia patients in a developed Southeast Asian country. International psychogeriatrics. 2013;25(9):1475-83.
Ding YY, Abisheganaden J, Chong WF, Heng BH, Lim TK. Effectiveness of acute geriatric units in the real world: the case of short-term mortality among seniors hospitalized for pneumonia. Geriatrics & gerontology international. 2013;13(1):55-62.
Feng L, Chong MS, Lim WS, Lee TS, Collinson SL, Yap P, et al. Metabolic syndrome and amnestic mild cognitive impairment: Singapore Longitudinal Ageing Study-2 findings. Journal of Alzheimer's disease. 2013;34(3):649-57.
Nagaendran K, Chen LH, Chong MS, Chua EV, …, Lim WS, et al . Ministry of health clinical practice guidelines: dementia. Singapore medical journal. 2013;54(5):293-8.
Neo HY, Tan KT, Ding YY. Higher than expected rates of seizures associated with the use of ertapenem in older hospitalized patients. Journal of Clinical Gerontology and Geriatrics. 2013;4(1):17-21.
Nyunt MS, Chong MS, Lim WS, Lee TS, Yap P, Ng TP. Reliability and Validity of the Clinical Dementia Rating for Community-Living Elderly Subjects without an Informant. Dementia and geriatric cognitive disorders extra. 2013;3(1):407-16.
Tay L, Chan M, Chong MS. Functional improvement in hospitalized older adults is independent of dementia diagnosis: experience of a specialized delirium management unit. Journal of hospital medicine. 2013;8(6):321-7.
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Special Issue: Dementia, Frailty and Aging

Welcome to this issue under Frontiers in Medicine which blends nicely with our research focuses of ageing brain (dementia) and frailty. This collection of 14 articles runs the gamut from insights in interface between cognition and physical domains, through to pertinent areas of caregiving and diagnosis in dementia, and evolving areas such as big data and microbes theory in brain ageing.

Find out more about the articles from here:

https://www.frontiersin.org/research-topics/5609/

https://doi.org/10.3389/fmed.2018.00168

2020/09/09