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The Clinical Research & Innovation Office (CRIO) promotes and coordinates research activities in TTSH. CRIO is equipped with skills and capabilities through her staff to effectively support the research enterprise of the Hospital.

Our Vision

Empowering clinical excellence through research and innovation

Our Mission

To provide comprehensive and sustainable research support for the Hospital by:

  • Providing valued resources in a timely and professional manner
  • Ensuring ethical and safety standards in the conduct of all types of research and innovation
  • Fostering and enhancing collaborations within and beyond TTSH

Our Services

​The CRIO Administration team provides advice on the appropriate types of agreements to be used for individual studies. 

We facilitate research collaboration activities with external parties placing appropriate research agreements to ensure studies or trials are conducted in accordance with all applicable laws and regulations.

Agreements are important to safeguard the safety and rights of the research participants and TTSH stakeholders.

Types of agreements:

  • Clinical Trial Agreement
  • Project Agreement
  • Research Collaboration Agreement
  • Service Agreement
  • Materials Transfer Agreement
  • Memorandum of Understanding
  • Addendum/Amendment Agreement
  • Licensing Agreement
  • Non-Disclosure/Confidentiality Agreement
  • Data Sharing Agreement

Funding is available from intramural and extramural sources, through grants, to enable hospital-employed researchers to pursue research projects.

For advice on collaborations and trials agreements, please connect with us through and include your study details, researcher information and IRB number (if applicable).

​The Policy and Monitoring section oversees the governance for research in TTSH, including research risk management, research policy formulation and implementation, internal and external audits and inspections as well as research training on proper conduct of research.

The section also ensures that the research activities conducted within TTSH comply with internal research policies, as well as the Good Clinical Practice guidelines of the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) and relevant Singapore laws and regulations.

In line with that, the monitoring team provides research monitoring services for investigator-initiated studies, including those regulated by Health Products (Clinical Trials) Regulations and the Human Biomedical Research Act.

We also handle research insurance matters, assist with regulatory submissions and manage matters related to and federal wide assurances.

To find out more how we can help you, please contact

​The Clinical Trials Unit (CTU) is the centralised unit promoting and coordinating high-quality clinical trials in TTSH.

The CTU matches potential pharmaceutical companies with our clinician researchers. We actively seek partnership with pharmaceutical companies and research institutes to develop the best care for our patients.

CTU has a team of GCP- (Good Clinical Practice) and CITI (Collaborative Institutional Training Initiative)-certified clinical research coordinators who conduct both early and late phase trials. Our coordinators are experienced in coordinating drug and device trials as well as registry studies in various therapeutic areas including:

  • Cardiology
  • Endocrinology
  • Gastroenterology & Hepatology
  • General Medicine
  • General Surgery
  • Geriatric Medicine
  • Haematology
  • Infectious Disease
  • Ophthalmology
  • Oncology
  • Psychological Medicine
  • Renal Medicine
  • Respiratory Medicine
  • Rheumatology

Partnership with CTU

If you would like to know more about conducting clinical trials in TTSH, please contact the Clinical Trials Unit at

​The Clinical Research Support team works with researchers throughout the research process, from study conception to data collection and publication of research findings.

Our team of an epidemiologist, data manager, medical writer and biostatisticians provides comprehensive support in accordance with local and international practice.

To find out more or to engage our team for our services, please contact

The CRIO epidemiologist’s role includes the following:

  • Conceptualise research questions
  • Select appropriate study design
  • Advise on potential bias and limitations of a study
  • Design questionnaires or clinical record forms
  • Advise database setting and data management
  • Provide support for presentations and manuscript writing
  • Address relevant comments from reviewers
  • Collaborate on research projects


CRIO statisticians perform the following tasks:

  • Formulate the research question and hypothesis
  • Advise on randomised controlled trial study design
  • Provide sample size estimation
  • Generate randomisation allocation code
  • Optimise data collection and cleaning
  • Analyse study data and interpret results
  • Provide technical writing support for presentations and manuscript writing
  • Address comments from reviewers
  • Provide statistical input for grant applications


​The CRIO data manager provides secure and cost-effective data management services. These include:

  • Database setup (Excel/Access/REDCap)
  • Data management support
  • Data validation
  • Data cleaning


The CRIO medical writer’s role includes the following:

  • Proofread manuscripts and grant applications
  • Provide editorial services for manuscripts and grants
  • Support grant writing
  • Support abstract or manuscript writing
  • Address comments from reviewers
  • Collaborate on research projects

The Clinical Innovation team facilitates partnerships between clinicians and technology companies to improve patient care and commercialise innovations.

Services available:
  • Innovation, collaboration and infrastructure support
  • Liaison work
  • Agreements management
  • Business negotiation
  • Intellectual property (IP) support
  • Project management

To discuss any clinical innovation ideas or to collaborate with us please contact

​CRIO runs a variety of courses to enhance the research skills of budding and experienced researchers.

We also facilitate the training and accreditation or certification for research personnel.

Ad hoc training can be provided on request.

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